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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1991-10-17
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pubmed:abstractText |
In decalcified (5% nitric acid) and undecalcified (glycol-methacrylate or resin embedded) routinely processed bone specimens osteoclasts against resorbing surfaces were identified with monoclonal antibodies directed against leucocyte common antigen (LCA) (PD7/26, 2B11), CD68 (KP1), and gpIIIa (Y2/51) but not against HLA-DR (CR3/43 and Ta11B5). Mononuclear cells on resorbing surfaces and occasional mononuclear cells against or near resting surfaces showed a similar pattern of reactivity. This study shows that immunohistochemistry is a sensitive and useful technique for identifying osteoclasts in routinely processed bone specimens. It also suggests a role for mononuclear cells (possibly pre-osteoclasts) in bone resorption.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-1689599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-2266187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-2654191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-2924719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-3192191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-3590236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-3881477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-4053038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-6183295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-6355845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-6707224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-6809291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-6876745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-7418318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1890200-94061
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9746
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
664-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1991
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pubmed:articleTitle |
Use of monoclonal antibodies to recognise osteoclasts in routinely processed bone biopsy specimens.
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pubmed:affiliation |
Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, Headington.
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pubmed:publicationType |
Journal Article
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