Linked Life Data

1890031

Source:http://linkedlifedata.com/resource/pubmed/id/1890031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-10-17
pubmed:abstractText
In samples collected from 170 dogs suspected of having hepatobiliary disease, preprandial serum bile acids (PRSBA) and postprandial serum bile acids (POSBA) concentrations were measured, using a spectrophotometric enzymatic method. Dogs were assigned to 8 disease groups and 1 control group on the basis of hepatic histopathologic findings. Pre- and postprandial SBA concentrations and results of routine biochemical analyses (including total bilirubin, albumin, and BUN concentrations, and serum alkaline phosphatase (ALP), alanine transaminase (ALT), and aspartate transaminase (AST) activities) were expressed, using 4 indices: sensitivity, specificity, positive predictive value, and negative predictive value. Single tests and combinations of tests in series were evaluated. For diagnosis of hepatobiliary disease, the specificity of PRSBA was 100% at values greater than 20 mumol/L and of POSBA was 100% at values greater than 25 mumol/L. Test combinations with the best sensitivity for diagnosing the following diseases were: PRSBA-POSBA for cirrhosis, portosystemic vascular anomaly, and glucocorticoid hepatopathy; PRSBA-POSBA or PRSBA-ALP for cholestasis; PRSBA-POSBA or ALT-AST for chronic hepatitis; PRSBA-ALT for hepatic necrosis and passive congestion; and PRSBA-ALP for neoplasia. Test combinations with the overall highest sensitivity and positive predictive value for the fewest number of tests were PRSBA-POSBA, and either PRSBA or POSBA combined with an enzyme activity (ALT, AST, or ALP). The overall test efficacy for PRSBA vs POSBA was nearly identical: for PRSBA, it was 82.4%, and for POSBA, it was 82.3%. On the basis of the results of this study, PRSBA greater than 20 mumol/L or POSBA greater than 25 mumol/L (measured by use of an enzymatic procedure) indicates histopathologic abnormalities of the hepatobiliary system or portosystemic vascular anastomosis. Seemingly, determination of SBA concentrations can be used to indicate the propriety for hepatic biopsy. Pre- and postprandial serum bile acids concentrations should be evaluated in conjunction with routinely used hepatobiliary screening tests for best diagnostic advantage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-1488
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
199
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1890031-Alanine Transaminase, pubmed-meshheading:1890031-Alkaline Phosphatase, pubmed-meshheading:1890031-Animals, pubmed-meshheading:1890031-Aspartate Aminotransferases, pubmed-meshheading:1890031-Bile Acids and Salts, pubmed-meshheading:1890031-Biliary Tract Diseases, pubmed-meshheading:1890031-Bilirubin, pubmed-meshheading:1890031-Blood Urea Nitrogen, pubmed-meshheading:1890031-Cholestasis, pubmed-meshheading:1890031-Dog Diseases, pubmed-meshheading:1890031-Dogs, pubmed-meshheading:1890031-Eating, pubmed-meshheading:1890031-Hepatitis, Animal, pubmed-meshheading:1890031-Liver Cirrhosis, pubmed-meshheading:1890031-Liver Diseases, pubmed-meshheading:1890031-Liver Neoplasms, pubmed-meshheading:1890031-Portal System, pubmed-meshheading:1890031-Predictive Value of Tests, pubmed-meshheading:1890031-Serum Albumin
pubmed:year
1991
pubmed:articleTitle
Evaluation of twelve-hour preprandial and two-hour postprandial serum bile acids concentrations for diagnosis of hepatobiliary disease in dogs.
pubmed:affiliation
Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't