Linked Life Data

1888172

Source:http://linkedlifedata.com/resource/pubmed/id/1888172

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-10-4
pubmed:abstractText
We have examined the expression of the epidermal growth factor receptor (EGFr) gene and 14 other oncogenes in several human gliomas. EGFr overexpression was apparent in 17 of 18 tumors. Nevertheless, remarkable amounts of aberrantly-sized EGFr mRNAs were not found in the 11 tumors examined. Among the 14 other oncogene probes employed, only the H-ras probe revealed changes in the expression level. The expression of this oncogene was 2-3-fold reduced in 13 of 18 tumors. In neural tissue the H-ras gene expression can be correlated with cellular differentiation. A correlation between H-ras protein expression and a favourable clinical prognosis was found in neuroblastomas. The decreased amounts of H-ras transcripts in gliomas may be a sign of a lower state of differentiation of the cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:geneSymbol
H-ras
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1353-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:articleTitle
In contrast to EGFr gene overexpression, H-ras gene expression decreases in human gliomas.
pubmed:affiliation
Institute of Neuropathology, Free University of Berlin, Klinikum Steglitz, F.R.G.
pubmed:publicationType
Journal Article