Linked Life Data

1888146

Source:http://linkedlifedata.com/resource/pubmed/id/1888146

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-10-4
pubmed:abstractText
The cytotoxic properties of the phenothiazines suggest the potential of phenothiazines as antitumor drugs. The following are some important characteristics of phenothiazines for antitumor research: (i) Phenothiazines show an inherent cytotoxicity which can be utilized in the treatment of tumors. (ii) Selective concentration of phenothiazines in tissues such as melanoma and brain tumors can be utilized in the treatment of such tumors. (iii). Structural modifications of phenothiazines with the substitution of a nitrogen atom may lead to more potent cytotoxic agents, particularly when used in combination with radiation. (iv) A synergic effect may be achieved when phenothiazines are used in combination with other agents and conditions. (v) More research is required for understanding the molecular mechanisms responsible for the cytotoxicity of phenothiazines. (vi) Phenothiazines seem to show both antitumor as well as anticarcinogenic properties. The latter property may be utilized in preventing the formation of tumors as well as in the treatment of tumors at very early stages of their development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1125-64
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Phenothiazines and calmodulin (review).
pubmed:affiliation
Department of Medicinal Chemistry, Meiji College of Pharmacy, Tokyo, Japan.
pubmed:publicationType
Journal Article, Review