|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3 Pt 2
|
|
pubmed:dateCreated |
1991-10-4
|
|
pubmed:abstractText |
The vasoconstrictor eicosanoid thromboxane plays an important role in the pathogenesis of several renal diseases. As an autacoid, its local release alters blood flow and induces platelet aggregation. We report a direct stimulatory effect of thromboxane on extracellular matrix protein production and gene expression in vitro. Treatment of two cell types, differentiated mouse teratocarcinoma cells (F9+) and human glomerular mesangial cells, with two different thromboxane analogues resulted in increased production of components of the extracellular matrix including fibronectin and the basement membrane proteins laminin and type IV collagen. These responses to thromboxane were not the result of a mitogenic effect of thromboxane nor the result of an increase in total cellular protein. The increased production of extracellular matrix proteins was, at least in part, due to an increase in the steady-state level of mRNA for these genes. Furthermore, the effect of thromboxane was markedly inhibited by cotreatment with a thromboxane-receptor antagonist. These results suggest a new potential role for thromboxane as a mediator of the sclerotic and fibrotic responses to injury.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9...,
http://linkedlifedata.com/resource/pubmed/chemical/7-(3-(3-hydroxy-4-(4'-iodophenoxy)-1...,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Heptanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin Endoperoxides...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxanes,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine,
http://linkedlifedata.com/resource/pubmed/chemical/vapiprost
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0002-9513
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
261
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
F488-94
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1887910-15-Hydroxy-11 alpha,9...,
pubmed-meshheading:1887910-Adult,
pubmed-meshheading:1887910-Animals,
pubmed-meshheading:1887910-Bicyclo Compounds,
pubmed-meshheading:1887910-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:1887910-Biphenyl Compounds,
pubmed-meshheading:1887910-Cell Division,
pubmed-meshheading:1887910-Cell Line,
pubmed-meshheading:1887910-Cells, Cultured,
pubmed-meshheading:1887910-Collagen,
pubmed-meshheading:1887910-DNA Replication,
pubmed-meshheading:1887910-Extracellular Matrix Proteins,
pubmed-meshheading:1887910-Fatty Acids, Unsaturated,
pubmed-meshheading:1887910-Fibronectins,
pubmed-meshheading:1887910-Glomerular Mesangium,
pubmed-meshheading:1887910-Heptanoic Acids,
pubmed-meshheading:1887910-Humans,
pubmed-meshheading:1887910-Kinetics,
pubmed-meshheading:1887910-Laminin,
pubmed-meshheading:1887910-Mice,
pubmed-meshheading:1887910-Prostaglandin Endoperoxides, Synthetic,
pubmed-meshheading:1887910-RNA, Messenger,
pubmed-meshheading:1887910-Teratoma,
pubmed-meshheading:1887910-Thromboxanes,
pubmed-meshheading:1887910-Thymidine
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Thromboxane stimulates synthesis of extracellular matrix proteins in vitro.
|
|
pubmed:affiliation |
Molecular Medicine Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
