| pubmed-article:18854107 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18854107 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:18854107 | lifeskim:mentions | umls-concept:C0029045 | lld:lifeskim |
| pubmed-article:18854107 | lifeskim:mentions | umls-concept:C0015914 | lld:lifeskim |
| pubmed-article:18854107 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:18854107 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:18854107 | lifeskim:mentions | umls-concept:C2936610 | lld:lifeskim |
| pubmed-article:18854107 | lifeskim:mentions | umls-concept:C0522501 | lld:lifeskim |
| pubmed-article:18854107 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18854107 | pubmed:dateCreated | 2008-10-15 | lld:pubmed |
| pubmed-article:18854107 | pubmed:abstractText | Enthusiasm for oocyte cryopreservation has been limited by poor pregnancy rates per thawed metaphase II (MII) oocytes (<4%) and low implantation rates per embryos. The reasons relate to technical limitations in the freezing process, and the fact that <40% of oocytes are euploid and unable to produce 'competent' embryos. Comparative genomic hybridization was performed on the first polar body (PB-1) of 323 MII oocytes retrieved from 16 donors. Of these, 111 were euploid, and were vitrified. Seventy-five of 78 vitrified oocytes (96%) survived warming and were fertilized using intracytoplasmic sperm injection. Thirty-one (41%) subsequently developed into expanded blastocysts, of which no more than two were subsequently transferred per uterus to 16 out of 19 prospective embryo recipients. Twelve of 19 (63%) recipients produced 17 healthy babies (eight singletons, three twins, and one set of triplets) One twin pregnancy miscarried in the late first trimester The birth rate per transfer of a maximum of two blastocysts to 16 recipients was 75%. The implantation rate per vitrified euploid oocyte was 27%. This study showed a six-fold improvement in pregnancy rate per cryopreserved oocyte over previous reports and a marked improvement in implantation rate. If independently validated, this approach could open the door to commercial egg cryobanking, significantly expanding women's reproductive choices. | lld:pubmed |
| pubmed-article:18854107 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18854107 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18854107 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18854107 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18854107 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18854107 | pubmed:issn | 1472-6491 | lld:pubmed |
| pubmed-article:18854107 | pubmed:author | pubmed-author:GinsburgMM | lld:pubmed |
| pubmed-article:18854107 | pubmed:author | pubmed-author:SherGG | lld:pubmed |
| pubmed-article:18854107 | pubmed:author | pubmed-author:MukaidaTT | lld:pubmed |
| pubmed-article:18854107 | pubmed:author | pubmed-author:MaassaraniGG | lld:pubmed |
| pubmed-article:18854107 | pubmed:author | pubmed-author:KeskintepeLL | lld:pubmed |
| pubmed-article:18854107 | pubmed:author | pubmed-author:BayramGG | lld:pubmed |
| pubmed-article:18854107 | pubmed:author | pubmed-author:BIENMM | lld:pubmed |
| pubmed-article:18854107 | pubmed:author | pubmed-author:KeskintepeMM | lld:pubmed |
| pubmed-article:18854107 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18854107 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:18854107 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18854107 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18854107 | pubmed:pagination | 524-9 | lld:pubmed |
| pubmed-article:18854107 | pubmed:meshHeading | pubmed-meshheading:18854107... | lld:pubmed |
| pubmed-article:18854107 | pubmed:meshHeading | pubmed-meshheading:18854107... | lld:pubmed |
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| pubmed-article:18854107 | pubmed:meshHeading | pubmed-meshheading:18854107... | lld:pubmed |
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| pubmed-article:18854107 | pubmed:meshHeading | pubmed-meshheading:18854107... | lld:pubmed |
| pubmed-article:18854107 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18854107 | pubmed:articleTitle | Selective vitrification of euploid oocytes markedly improves survival, fertilization and pregnancy-generating potential. | lld:pubmed |
| pubmed-article:18854107 | pubmed:affiliation | 2Department of Obstetrics and Gynecology, Sher Institutes for Reproductive Medicine, University of Nevada School of Medicine, Reno, NV 89109 , USA. gsher@sherinstitute.com | lld:pubmed |
| pubmed-article:18854107 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18854107 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18854107 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18854107 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18854107 | lld:pubmed |
