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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-10-29
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pubmed:abstractText |
We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1546-1718
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pubmed:author |
pubmed-author:AlblasMargrieta AMA,
pubmed-author:BaurMax PMP,
pubmed-author:BeckerTimT,
pubmed-author:BetzRegina CRC,
pubmed-author:Bröcker-PreussMartinaM,
pubmed-author:BrockschmidtFelix FFF,
pubmed-author:CichonSvenS,
pubmed-author:EigelshovenSibylleS,
pubmed-author:ErbelRaimundR,
pubmed-author:FlaquerAntoniaA,
pubmed-author:HannekenSandraS,
pubmed-author:HermsStefanS,
pubmed-author:HillmerAxel MAM,
pubmed-author:JöckelKarl-HeinzKH,
pubmed-author:KortümAnne-KatrinAK,
pubmed-author:KruseRolandR,
pubmed-author:MühleisenThomas WTW,
pubmed-author:MartinNicholas GNG,
pubmed-author:MoebusSusanneS,
pubmed-author:MontgomeryGrant WGW,
pubmed-author:NöthenMarkus MMM,
pubmed-author:NyholtDale RDR,
pubmed-author:ProppingPeterP,
pubmed-author:ReinartzRomanR,
pubmed-author:SteffensMichaelM,
pubmed-author:WienkerThomas FTF,
pubmed-author:ZhaoZhen ZhenZZ
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1279-81
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pubmed:dateRevised |
2010-4-13
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pubmed:meshHeading |
pubmed-meshheading:18849994-Adult,
pubmed-meshheading:18849994-Alopecia,
pubmed-meshheading:18849994-Chromosomes, Human, Pair 20,
pubmed-meshheading:18849994-Female,
pubmed-meshheading:18849994-Genetic Predisposition to Disease,
pubmed-meshheading:18849994-Genome, Human,
pubmed-meshheading:18849994-Germany,
pubmed-meshheading:18849994-Humans,
pubmed-meshheading:18849994-Male,
pubmed-meshheading:18849994-Polymorphism, Single Nucleotide
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pubmed:year |
2008
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pubmed:articleTitle |
Susceptibility variants for male-pattern baldness on chromosome 20p11.
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pubmed:affiliation |
Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany. axel.hillmer@uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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