Source:http://linkedlifedata.com/resource/pubmed/id/18848823
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2008-11-25
|
| pubmed:abstractText |
Dedifferentiation, or decreased processing specificity, has been suggested to represent a ubiquitous characteristic of cognitive aging. In this study, we examined both age-related differences and intra-group differences in neural specificity in the ventral visual cortex for color, words, faces and places. Our results demonstrated that neural dedifferentiation was not ubiquitous across stimulus categories. Neural dedifferentiation was also relatively stable, across age, in a group of older adults. Older adults with more overall gray matter showed less neural dedifferentiation in the visual cortex. However, regional gray matter volume was not associated with neural dedifferentiation. We illustrate these effects using a discriminability metric, a signal detection theory measure, for neural dedifferentiation that takes into account both magnitude and variance of brain activation. The dedifferentiation measure provides a quantitative means to examine activation patterns and individual difference factors associated with neural dedifferentiation, and to test theories of behavioral dedifferentiation in cognitive aging literature.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1872-6240
|
| pubmed:author |
pubmed-author:ChaddockLauraL,
pubmed-author:ColcombeStanley JSJ,
pubmed-author:DoerksenShawnaS,
pubmed-author:EricksonKirk IKI,
pubmed-author:HuLiangL,
pubmed-author:KramerArthur FAF,
pubmed-author:McAuleyEdwardE,
pubmed-author:MorrisKatherine SKS,
pubmed-author:PrakashRuchika SRS,
pubmed-author:VossMichelle WMW
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
9
|
| pubmed:volume |
1244
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
121-31
|
| pubmed:meshHeading |
pubmed-meshheading:18848823-Adult,
pubmed-meshheading:18848823-Age Factors,
pubmed-meshheading:18848823-Aged,
pubmed-meshheading:18848823-Aged, 80 and over,
pubmed-meshheading:18848823-Aging,
pubmed-meshheading:18848823-Color Perception,
pubmed-meshheading:18848823-Dominance, Cerebral,
pubmed-meshheading:18848823-Face,
pubmed-meshheading:18848823-Female,
pubmed-meshheading:18848823-Humans,
pubmed-meshheading:18848823-Image Processing, Computer-Assisted,
pubmed-meshheading:18848823-Individuality,
pubmed-meshheading:18848823-Magnetic Resonance Imaging,
pubmed-meshheading:18848823-Male,
pubmed-meshheading:18848823-Middle Aged,
pubmed-meshheading:18848823-Photic Stimulation,
pubmed-meshheading:18848823-Reaction Time,
pubmed-meshheading:18848823-Visual Cortex,
pubmed-meshheading:18848823-Visual Perception,
pubmed-meshheading:18848823-Young Adult
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Dedifferentiation in the visual cortex: an fMRI investigation of individual differences in older adults.
|
| pubmed:affiliation |
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. mvoss@uiuc.edu
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, N.I.H., Extramural
|