Source:http://linkedlifedata.com/resource/pubmed/id/18848593
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
52
|
| pubmed:dateCreated |
2008-12-1
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| pubmed:abstractText |
A H5N2 low pathogenic avian influenza virus (LPAIV) was isolated from a natural reservoir in Bavaria during a routine screen and was used as a vaccine strain to scrutinize the immune response involved in cross-protection after challenge infection with a H5N1 highly pathogenic avian influenza virus (HPAIV). The challenge virus was also isolated from a natural reservoir in Bavaria. Wild type, antibody deficient (muMT), CD4(-/-) and CD8(-/-) mice were infected with the apathogenic H5N2 vaccine strain and challenge infection with a 100-fold MLD(50) of the H5N1 strain was performed 80 days later. While 100% of the wild type and 100% of the CD8(-/-) mice stayed healthy, only 50% of the CD4(-/-) and none of the antibody deficient mice were protected. These results support the view that the humoral immune response and to certain extends the CD4(+) T helper cells are a prerequisite for cross-protective immunity against H5 influenza virus.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0264-410X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
9
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
6965-74
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18848593-Animals,
pubmed-meshheading:18848593-Antibodies, Viral,
pubmed-meshheading:18848593-Antibody Formation,
pubmed-meshheading:18848593-Antibody Specificity,
pubmed-meshheading:18848593-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18848593-Cell Line,
pubmed-meshheading:18848593-Cross Reactions,
pubmed-meshheading:18848593-Female,
pubmed-meshheading:18848593-Flow Cytometry,
pubmed-meshheading:18848593-Hemagglutination Inhibition Tests,
pubmed-meshheading:18848593-Immunity, Cellular,
pubmed-meshheading:18848593-Immunocompetence,
pubmed-meshheading:18848593-Influenza A Virus, H5N1 Subtype,
pubmed-meshheading:18848593-Influenza A Virus, H5N2 Subtype,
pubmed-meshheading:18848593-Influenza Vaccines,
pubmed-meshheading:18848593-Lymphocyte Count,
pubmed-meshheading:18848593-Male,
pubmed-meshheading:18848593-Mice,
pubmed-meshheading:18848593-Mice, Inbred C57BL,
pubmed-meshheading:18848593-Neutralization Tests,
pubmed-meshheading:18848593-Orthomyxoviridae Infections,
pubmed-meshheading:18848593-Respiratory System,
pubmed-meshheading:18848593-Vaccination,
pubmed-meshheading:18848593-Viral Plaque Assay
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Antibodies and CD4(+) T-cells mediate cross-protection against H5N1 influenza virus infection in mice after vaccination with a low pathogenic H5N2 strain.
|
| pubmed:affiliation |
Friedrich-Loeffler-Institut, Institute of Immunology, Paul-Ehrlich Str. 28, D-72076 Tübingen, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|