Linked Life Data

18847482

Source:http://linkedlifedata.com/resource/pubmed/id/18847482

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-10-17
pubmed:abstractText
Exacerbations are a major cause of morbidity and mortality in chronic obstructive pulmonary disease. Exacerbations can be of bacterial, viral or mixed etiology, with bacteria involved in 50% of exacerbations. Consequently, current management of exacerbations frequently involves the use of antibiotics. The paper by Puhan et al published this month in BMC Medicine examines the benefit of antibiotics in placebo-controlled trials in mild to moderate outpatient exacerbations. The authors use a meta-analytic approach and rightly conclude that more trials are needed in this area. However, the heterogeneity of chronic obstructive pulmonary disease patients and exacerbations and the limited end-points in past trials do not allow firm conclusions to be drawn about antibiotic use in outpatient exacerbations based on this meta-analysis. Future trials need to take into account this heterogeneity as well as incorporate novel end-points to address this important issue.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-11273797, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-11281745, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-11488328, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-12017408, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-15006954, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-1589668, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-16113422, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-16449273, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-17573508, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-18847478, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-3492164, http://linkedlifedata.com/resource/pubmed/commentcorrection/18847482-7570411
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1741-7015
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The problems of meta-analysis for antibiotic treatment of chronic obstructive pulmonary disease, a heterogeneous disease: a commentary on Puhan et al.
pubmed:affiliation
Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, State University of New York and VA Western New York Healthcare System, Buffalo, New York, USA. ssethi@buffalo.edu
pubmed:publicationType
Editorial, Comment