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rdf:type |
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|
lifeskim:mentions |
umls-concept:C0005823,
umls-concept:C0017337,
umls-concept:C0025266,
umls-concept:C0037494,
umls-concept:C0086860,
umls-concept:C0086907,
umls-concept:C0388389,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1708715,
umls-concept:C1882417,
umls-concept:C2346689,
umls-concept:C2911692
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pubmed:issue |
6
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|
pubmed:dateCreated |
2008-10-10
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|
pubmed:abstractText |
The family of aquaporin water channels contributes to water and salt homeostasis. AQP5 is a ubiquitously expressed exocrine-type water channel. Functional single nucleotide polymorphisms in AQP5 which alter gene transcription have not yet been described. We, therefore, sequenced the human AQP5 promoter to detect novel sequence variants which could impact upon AQP5 expression and contribute to the phenotypic variability of the renin-angiotensin-aldosterone system (RAAS).
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1435-1803
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
598-610
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pubmed:meshHeading |
pubmed-meshheading:18846354-Adult,
pubmed-meshheading:18846354-Aged,
pubmed-meshheading:18846354-Aldosterone,
pubmed-meshheading:18846354-Alleles,
pubmed-meshheading:18846354-Angiotensin II,
pubmed-meshheading:18846354-Aquaporin 5,
pubmed-meshheading:18846354-Blood Pressure,
pubmed-meshheading:18846354-Case-Control Studies,
pubmed-meshheading:18846354-Cohort Studies,
pubmed-meshheading:18846354-Coronary Artery Disease,
pubmed-meshheading:18846354-Female,
pubmed-meshheading:18846354-Homeostasis,
pubmed-meshheading:18846354-Humans,
pubmed-meshheading:18846354-Male,
pubmed-meshheading:18846354-Middle Aged,
pubmed-meshheading:18846354-Polymorphism, Single Nucleotide,
pubmed-meshheading:18846354-RNA, Messenger,
pubmed-meshheading:18846354-Renin-Angiotensin System,
pubmed-meshheading:18846354-Sodium Chloride, Dietary
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pubmed:year |
2008
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pubmed:articleTitle |
A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men.
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|
pubmed:affiliation |
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Germany. michael.adamzik@uk-essen.de
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pubmed:publicationType |
Journal Article,
Comparative Study
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