Source:http://linkedlifedata.com/resource/pubmed/id/18846280
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2008-10-10
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pubmed:abstractText |
The growing number of sequenced prokaryotic genomes reveals a wide distribution of open reading frames (ORFs) that putatively encode for red- and blue light sensing photoreceptors. They comprise the bilin-binding phytochromes and the flavin-binding cryptochromes, LOV and BLUF proteins, indicating that about 1/4 of bacteria do possess at least one of these photosensory proteins. The distribution of red- and blue-light sensors among different prokaryotic phyla and classes, and their functional activity as light-switched systems are the subject of this perspective. These photoreceptors were originally found in plants by following the associated physiological responses induced by the respective spectral irradiation. Genome-based approaches now require the assignment of a photochemical/physiological function to the heterologously expressed gene product. Database searches demonstrate in some cases several genes of one category in a certain prokaryot, indicating the presence of more than one type of red- or blue-light sensing properties, but also show a combination of proteins with both spectral sensitivities. Another interesting feature now "comes into light": according to their nature as biological sensors, these photoreceptors are equipped with signalling domains, initiating a cellular response, thereby constituting modular systems switchable by light. It is seen that many of these signalling domains, now found together with light-inducible sensing domains, were already described for other stimuli, e.g., osmo-regulation, oxygen, hydrogen, chemicals, or pH. In some cases, the same type of signalling domain can be found in a red- or a blue-light sensing photoreceptor. Following the characterization of their photochemistry, for several of these bacterial photoreceptors physiological functions are now assigned.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1474-905X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1168-78
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pubmed:meshHeading |
pubmed-meshheading:18846280-Bacteria,
pubmed-meshheading:18846280-Bacterial Proteins,
pubmed-meshheading:18846280-Bile Pigments,
pubmed-meshheading:18846280-Binding Sites,
pubmed-meshheading:18846280-Flavins,
pubmed-meshheading:18846280-Light,
pubmed-meshheading:18846280-Photochemistry,
pubmed-meshheading:18846280-Photoreceptors, Microbial
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pubmed:year |
2008
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pubmed:articleTitle |
Bacterial bilin- and flavin-binding photoreceptors.
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pubmed:affiliation |
Department of Physics, University of Parma, Italy.
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pubmed:publicationType |
Journal Article,
Review
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