Source:http://linkedlifedata.com/resource/pubmed/id/18845941
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
2008-10-10
|
| pubmed:abstractText |
Accumulated evidence indicates chronic systemic injection of D-galactose mimics aging progress induced by oxidative stress. We addressed whether memory impairment in this model was associated with the cholinergic septohippocampal degeneration. Rats injected with D-galactose for 6 weeks showed impairment of spatial learning and memory as measured by the water maze test. Correspondingly, anti-choline acetyltransferase immunohistochemistry demonstrated a severe loss of cholinergic terminals in the hippocampus accompanied by a mild cholinergic neuronal atrophy and loss in the medial septum and the nucleus of the vertical limb of the diagonal band of Broca. A major synaptic degeneration in the hippocampus was confirmed by ultrastructural analysis. These findings provide neuropathological evidence for rodents with chronic injection of D-galactose as a promising model for brain aging and age-related neurodegeneration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1473-558X
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
29
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1611-5
|
| pubmed:meshHeading |
pubmed-meshheading:18845941-Aging,
pubmed-meshheading:18845941-Animals,
pubmed-meshheading:18845941-Behavior, Animal,
pubmed-meshheading:18845941-Choline O-Acetyltransferase,
pubmed-meshheading:18845941-Galactose,
pubmed-meshheading:18845941-Hippocampus,
pubmed-meshheading:18845941-Immunohistochemistry,
pubmed-meshheading:18845941-Injections, Subcutaneous,
pubmed-meshheading:18845941-Male,
pubmed-meshheading:18845941-Maze Learning,
pubmed-meshheading:18845941-Memory,
pubmed-meshheading:18845941-Microscopy, Electron,
pubmed-meshheading:18845941-Nerve Degeneration,
pubmed-meshheading:18845941-Neurons,
pubmed-meshheading:18845941-Rats,
pubmed-meshheading:18845941-Rats, Sprague-Dawley,
pubmed-meshheading:18845941-Septal Nuclei,
pubmed-meshheading:18845941-Spatial Behavior,
pubmed-meshheading:18845941-Synapses
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Chronic systemic injection of D-galactose impairs the septohippocampal cholinergic system in rats.
|
| pubmed:affiliation |
Key Laboratory of Neurodegeneration, Department of Anatomy, Histology and Pharmacology, Jiangsu Province Nanjing Medical University, Nanjing, Jiangsu, P.R. China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|