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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-10-8
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pubmed:abstractText |
Reduced function mutations in the insulin/IGF-I signaling pathway increase maximal lifespan and health span in many species. Calorie restriction (CR) decreases serum IGF-1 concentration by ~40%, protects against cancer and slows aging in rodents. However, the long-term effects of CR with adequate nutrition on circulating IGF-1 levels in humans are unknown. Here we report data from two long-term CR studies (1 and 6 years) showing that severe CR without malnutrition did not change IGF-1 and IGF-1 : IGFBP-3 ratio levels in humans. In contrast, total and free IGF-1 concentrations were significantly lower in moderately protein-restricted individuals. Reducing protein intake from an average of 1.67 g kg(-1) of body weight per day to 0.95 g kg(-1) of body weight per day for 3 weeks in six volunteers practicing CR resulted in a reduction in serum IGF-1 from 194 ng mL(-1) to 152 ng mL(-1). These findings demonstrate that, unlike in rodents, long-term severe CR does not reduce serum IGF-1 concentration and IGF-1 : IGFBP-3 ratio in humans. In addition, our data provide evidence that protein intake is a key determinant of circulating IGF-1 levels in humans, and suggest that reduced protein intake may become an important component of anticancer and anti-aging dietary interventions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-10647962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-11371619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-12483226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-12499330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-12663691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-15096581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-15734678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-15924568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-16123266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-16412867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-16574059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-16682650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-16720655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-16770005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-16931767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-16960025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-17093155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-17158430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-17237261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-17341713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-17389710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-17518696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-17684529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-19281498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-7197688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-7758431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-8001743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-8156941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18843793-9354418
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1474-9726
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
681-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18843793-Aging,
pubmed-meshheading:18843793-Caloric Restriction,
pubmed-meshheading:18843793-Dietary Proteins,
pubmed-meshheading:18843793-Energy Intake,
pubmed-meshheading:18843793-Female,
pubmed-meshheading:18843793-Humans,
pubmed-meshheading:18843793-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:18843793-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:18843793-Insulin-Like Growth Factor I,
pubmed-meshheading:18843793-Male,
pubmed-meshheading:18843793-Middle Aged,
pubmed-meshheading:18843793-Protein Deficiency,
pubmed-meshheading:18843793-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.
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pubmed:affiliation |
Division of Geriatrics & Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA. lfontana@dom.wustl.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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