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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
6
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|
pubmed:dateCreated |
2008-11-17
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|
pubmed:abstractText |
Patients infected with hepatitis C virus (HCV) genotype 2 or 3 usually respond better to interferon (IFN) treatment than those infected with genotype 1. In this study, we investigated whether the non-structural 5A protein (NS5A) of HCV genotypes 1 and 2 (1b-NS5A and 2a-NS5A, respectively) exerted differential counteractivities against IFN treatment.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Dec
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|
pubmed:issn |
0168-8278
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
49
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
899-907
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|
pubmed:meshHeading |
pubmed-meshheading:18842320-Amino Acid Sequence,
pubmed-meshheading:18842320-Animals,
pubmed-meshheading:18842320-Antiviral Agents,
pubmed-meshheading:18842320-Cercopithecus aethiops,
pubmed-meshheading:18842320-Drug Resistance, Viral,
pubmed-meshheading:18842320-Genotype,
pubmed-meshheading:18842320-HeLa Cells,
pubmed-meshheading:18842320-Hepacivirus,
pubmed-meshheading:18842320-Hepatitis C,
pubmed-meshheading:18842320-Humans,
pubmed-meshheading:18842320-Interferon-alpha,
pubmed-meshheading:18842320-Molecular Sequence Data,
pubmed-meshheading:18842320-Promoter Regions, Genetic,
pubmed-meshheading:18842320-Protein Structure, Tertiary,
pubmed-meshheading:18842320-Signal Transduction,
pubmed-meshheading:18842320-Transcription, Genetic,
pubmed-meshheading:18842320-Transfection,
pubmed-meshheading:18842320-Vero Cells,
pubmed-meshheading:18842320-Viral Nonstructural Proteins
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pubmed:year |
2008
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|
pubmed:articleTitle |
The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism.
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|
pubmed:affiliation |
Graduate Institute of Microbiology, National Taiwan University College of Medicine, Taipei 100, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
