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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1991-10-10
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pubmed:abstractText |
In order to learn more about the vulnerability of nerve fibres to ischemia, a quantitative study of nerve fibre abnormalities was performed on biopsy specimens of the superficial branch of the peroneal nerve from 26 patients with vasculitic neuropathy: 20 had necrotizing arteritis, 5 a lymphocytic, and 1 a leucocytoclastic vasculitis on nerve and/or muscle biopsy. The density of myelinated fibres ranged from 25 to 7880 per mm2 (n = 8470 +/- 706 (SD]. There was a marked inequality in the density of nerve fibres between the fascicles of individual nerves with a mean coefficient of variation of 41 +/- 37 (SD) % versus 7.4 +/- 3.0% in controls. Loss of myelinated fibres, which was greater for fibres larger than 7 microns in diameter, was more severe than that for unmyelinated axons. Regeneration, which was assessed by the number of clustered axons, decreased when the density of myelinated fibres decreased, suggesting that severe nerve ischaemia precludes axonal regeneration. Wallerian degeneration affected on average 58% (range 5-100%) and segmental demyelination, mainly of the secondary type, on average 1.94% (range 1-10%) of teased fibres. It was concluded that (1) myelinated fibres are more vulnerable to ischaemia than unmyelinated axons; (2) large myelinated fibres are affected before the smaller ones; (3) segmental demyelination is uncommon in this context; (4) severe nerve ischaemia precludes axonal regeneration.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-8950
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
114 ( Pt 4)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1929-42
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1884186-Adult,
pubmed-meshheading:1884186-Aged,
pubmed-meshheading:1884186-Axons,
pubmed-meshheading:1884186-Disease Susceptibility,
pubmed-meshheading:1884186-Female,
pubmed-meshheading:1884186-Humans,
pubmed-meshheading:1884186-Ischemia,
pubmed-meshheading:1884186-Male,
pubmed-meshheading:1884186-Middle Aged,
pubmed-meshheading:1884186-Nerve Fibers,
pubmed-meshheading:1884186-Nerve Fibers, Myelinated,
pubmed-meshheading:1884186-Nervous System,
pubmed-meshheading:1884186-Time Factors,
pubmed-meshheading:1884186-Vasculitis
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pubmed:year |
1991
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pubmed:articleTitle |
Vulnerability of nerve fibres to ischaemia. A quantitative light and electron microscope study.
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pubmed:affiliation |
Service de Neurologie, Hôpital de Bicêtre, Université Paris XI, France.
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pubmed:publicationType |
Journal Article
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