Linked Life Data

18840506

Source:http://linkedlifedata.com/resource/pubmed/id/18840506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-10-30
pubmed:abstractText
There is increasing evidence that impairment of mitochondrial function and oxidative damage are contributing factors to the pathophysiology of Parkinson's disease (PD). Studies have reported decreased levels of the mitochondrial electron transport chain carrier, coenzyme Q(10) (CoQ(10)) in plasma and platelets from PD patients. Although a deficit in peripheral CoQ(10) has been reported no studies have assessed the CoQ(10) status of the PD brain. In this study we investigated the CoQ(10) status of the substantia nigra, cerebellum, cortex and striatum brain regions of both PD patients and age-matched controls. The results of this study indicate a significant reduction (p=0.007) in CoQ(10) concentration in the cortex region of the brain. In conclusion, the results of this study indicate evidence of a deficit in brain CoQ(10) status may be involved in the pathophysiology of PD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
447
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The coenzyme Q10 status of the brain regions of Parkinson's disease patients.
pubmed:affiliation
Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London, UK. ihargrea@ion.ucl.uk
pubmed:publicationType
Journal Article