Linked Life Data

18839938

Source:http://linkedlifedata.com/resource/pubmed/id/18839938

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2008-11-6
pubmed:abstractText
Novel structural analogues of a HDAC inhibitor FK228 have been synthesized by modifying the most synthetically challenging unit, (3 S,4 E)-3-hydroxy-7-mercaptoheptenoic acid, with simple isosteric substitutions. These changes did not alter the backbone structure from FK228 but enabled facile and rapid synthesis by using readily available starting materials and high-yielding reactions. FK228 analogues were examined for their antitumoral activity on a variety of human cancer cells and led to the identification of new potent compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1520-4804
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6639-41
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Efficient solid-phase synthesis of FK228 analogues as potent antitumoral agents.
pubmed:affiliation
Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75080, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't