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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1991-10-7
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pubmed:abstractText |
Strategies have been developed to rid bone marrow of microscopic tumor prior to infusion in the autologous bone marrow transplant setting. We have previously demonstrated that recombinant human interleukin-2 (IL-2) is effective in such an experimental setting involving a methylcholanthrene-induced fibrosarcoma in mice. The purpose of the current work was to determine whether IL-2 treatment after, or before and after bone marrow transplantation would influence bone marrow engraftment or degree of hematologic reconstitution. We found that stem cell number (CFU-S) and posttransplant marrow cellularity were comparable in IL-2-treated or saline-treated mice. Furthermore, after engraftment, marrow stem cell and myeloid progenitor cell numbers were greater in the IL-2 treatment group. These results suggest that IL-2 will prove to be safe when administered in bone marrow transplant patients.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1056-5477
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
10
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1883912-Animals,
pubmed-meshheading:1883912-Bone Marrow Transplantation,
pubmed-meshheading:1883912-Colony-Forming Units Assay,
pubmed-meshheading:1883912-Female,
pubmed-meshheading:1883912-Granulocytes,
pubmed-meshheading:1883912-Humans,
pubmed-meshheading:1883912-Interleukin-2,
pubmed-meshheading:1883912-Kinetics,
pubmed-meshheading:1883912-Macrophages,
pubmed-meshheading:1883912-Mice,
pubmed-meshheading:1883912-Mice, Inbred C57BL,
pubmed-meshheading:1883912-Recombinant Proteins
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pubmed:year |
1991
|
pubmed:articleTitle |
The effects of interleukin-2 on bone marrow engraftment in a murine model.
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pubmed:affiliation |
Department of Medicine, University of Wisconsin-Madison 53706.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|