|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1991-10-9
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|
pubmed:abstractText |
The effect of the conformational state of the ADP/ATP-antiporter on the efficiency of inhibition by cyclosporine A of the Ca(2+)-induced increase of nonspecific permeability of the inner mitochondrial membrane was under study. It was found that the ADP/ATP-antiporter inhibitor carboxyatractyloside is able to reverse the cyclosporine A-induced inhibition of this nonspecific permeability. The effect of carbocyatractyloside is manifested only in mitochondria depleted of adenine nucleotides. The bifunctional SH-reagent phenylarsine oxide is also able to reverse the cyclosporine A effect. The data obtained testify to the fact that inhibition by cyclosporine A of nonspecific permeability is due to its effect on the conformational state of the ADP/ATP-antiporter.
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pubmed:language |
rus
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0320-9725
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
56
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
536-41
|
|
pubmed:dateRevised |
2007-7-23
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|
pubmed:meshHeading |
pubmed-meshheading:1883908-Arsenicals,
pubmed-meshheading:1883908-Calcium,
pubmed-meshheading:1883908-Cyclosporins,
pubmed-meshheading:1883908-Ethylmaleimide,
pubmed-meshheading:1883908-Intracellular Membranes,
pubmed-meshheading:1883908-Mersalyl,
pubmed-meshheading:1883908-Mitochondria, Liver,
pubmed-meshheading:1883908-Mitochondrial ADP, ATP Translocases,
pubmed-meshheading:1883908-Permeability
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
[The role of the ADP/ATP-antiporter in the inhibition of nonspecific permeability of the inner mitochondrial membrane by cyclosporin A].
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|
pubmed:publicationType |
Journal Article,
English Abstract
|
