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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2008-10-7
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pubmed:abstractText |
Different loss-of-function mutations were identified underlying PGRN haploinsufficiency in patients with frontotemporal lobar degeneration. PGRN mutations were also identified in other neurodegenerative brain diseases such as amyotrophic lateral sclerosis and Alzheimer disease, though their biologic contribution to these diseases remains elusive. Because of its apparent role in neuronal survival, we argued that PGRN might also contribute to Parkinson disease (PD) pathogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1526-632X
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pubmed:author |
pubmed-author:CorsmitEE,
pubmed-author:CrasPP,
pubmed-author:De DeynP PPP,
pubmed-author:EngelborghsSS,
pubmed-author:MattheijssensMM,
pubmed-author:NuytemansKK,
pubmed-author:PaleBB,
pubmed-author:PeetersKK,
pubmed-author:PickutBB,
pubmed-author:SleegersKK,
pubmed-author:TheunsJJ,
pubmed-author:Van BroeckhovenCC
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1147-51
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pubmed:dateRevised |
2009-2-25
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pubmed:meshHeading |
pubmed-meshheading:18838661-Aged,
pubmed-meshheading:18838661-Amino Acid Sequence,
pubmed-meshheading:18838661-Female,
pubmed-meshheading:18838661-Genetic Predisposition to Disease,
pubmed-meshheading:18838661-Genetic Variation,
pubmed-meshheading:18838661-Humans,
pubmed-meshheading:18838661-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:18838661-Male,
pubmed-meshheading:18838661-Middle Aged,
pubmed-meshheading:18838661-Molecular Sequence Data,
pubmed-meshheading:18838661-Mutation, Missense,
pubmed-meshheading:18838661-Parkinson Disease,
pubmed-meshheading:18838661-Polymorphism, Single Nucleotide,
pubmed-meshheading:18838661-Retrospective Studies,
pubmed-meshheading:18838661-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Progranulin variability has no major role in Parkinson disease genetic etiology.
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pubmed:affiliation |
Neurodegenerative Brain Diseases Group, VIB-Department of Molecular Genetics, University of Antwerp-CDE, Universiteitsplein 1, B-2610 Antwerpen, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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