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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-12-3
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pubmed:abstractText |
Ikaros is the prototypic member of a Kruppel-like zinc finger transcription factor subfamily that is required for normal hematopoietic cell differentiation and proliferation, particularly in the lymphoid lineages. Alternative splicing can generate multiple Ikaros isoforms that lack different numbers of exons and have different functions. Shorter isoforms, which lack the amino-terminal domain that mediates sequence-specific DNA binding, exert a dominant negative effect and inhibit the ability of longer heterodimer partners to bind DNA.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:ArrugaFrancescaF,
pubmed-author:BaccaraniMicheleM,
pubmed-author:BaruzziAnnaA,
pubmed-author:BertonGiorgioG,
pubmed-author:ChiarettiSabinaS,
pubmed-author:CilloniDanielaD,
pubmed-author:FerrariAnnaA,
pubmed-author:FerrariSimonaS,
pubmed-author:FoàRobinR,
pubmed-author:IacobucciIlariaI,
pubmed-author:LonettiAnnalisaA,
pubmed-author:MüschenMarkusM,
pubmed-author:MartinelliGiovanniG,
pubmed-author:MessaFrancescaF,
pubmed-author:OttavianiEmanuelaE,
pubmed-author:PaneFabrizioF,
pubmed-author:PaoliniStefaniaS,
pubmed-author:PapayannidisCristinaC,
pubmed-author:PiccalugaPier PaoloPP,
pubmed-author:SaglioGiuseppeG,
pubmed-author:SoveriniSimonaS,
pubmed-author:VignettiMarcoM,
pubmed-author:VitaleAntonellaA,
pubmed-author:ZuntiniRobertaR
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pubmed:issnType |
Electronic
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1814-21
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pubmed:dateRevised |
2010-6-7
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pubmed:meshHeading |
pubmed-meshheading:18838475-Adolescent,
pubmed-meshheading:18838475-Adult,
pubmed-meshheading:18838475-Aged,
pubmed-meshheading:18838475-DNA, Complementary,
pubmed-meshheading:18838475-Electrophoresis, Capillary,
pubmed-meshheading:18838475-Humans,
pubmed-meshheading:18838475-Ikaros Transcription Factor,
pubmed-meshheading:18838475-Middle Aged,
pubmed-meshheading:18838475-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:18838475-RNA, Messenger,
pubmed-meshheading:18838475-Young Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Identification of different Ikaros cDNA transcripts in Philadelphia-positive adult acute lymphoblastic leukemia by a high-throughput capillary electrophoresis sizing method.
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pubmed:affiliation |
Department of Hematology/Oncology L. and A. Seràgnoli S.Orsola Malpighi Hospital, University of Bologna, Bologna, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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