Linked Life Data

18837786

Source:http://linkedlifedata.com/resource/pubmed/id/18837786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-10-7
pubmed:abstractText
SUMMARY: Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is increasingly being isolated in the United States and several European countries. The correlates of protective immunity against this intracellular bacterium are not known, and currently there are no licensed vaccines available for human use. Cell-mediated immunity has long been believed to be critical for protection, and the importance of humoral immunity is also now recognized. Furthermore, synergy between antibodies, T cell-derived cytokines, and phagocytes appears to be critical to achieve sterilizing immunity against F. tularensis. Thus, novel vaccine approaches should be designed to induce robust antibody and cell-mediated immune responses to this pathogen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1600-065X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
225
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
244-55
pubmed:dateRevised
2011-6-14
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis.
pubmed:affiliation
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural