Source:http://linkedlifedata.com/resource/pubmed/id/18836908
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2008-10-6
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pubmed:abstractText |
1. Anticoccidials are widely used as food additives to prevent and treat coccidiosis. They are licensed for use in a prescribed concentration and during a specific time interval with broilers and pullets, but not for laying hens. 2. This study was set up to develop a new high pressure liquid chromatography (HPLC) method to detect clazuril (CZ: (+/-)-2-chloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile) in egg yolk and albumen and in plasma; to investigate both the presence of residues of CZ in eggs and its pharmacokinetic behaviour in laying hens. 3. A single oral dose (3 mg/kg BW) and multiple oral doses (3 mg/kg BW for 5 d) were investigated. The analytical method gave very good recovery (64 to 74%) in the three different matrices (yolk, albumen and plasma); precision and accuracy were within 11%. 4. After a single dose no residue was detected in eggs collected for up to 10 d, while following multiple dose treatment, CZ residues were detected until 10 d after the end of treatment. The concentration of the drug was higher in yolk than in albumen with a maximum ratio of 10 : 1. 5. Pharmacokinetics of CZ in laying hens after a single dose showed a detectable concentration of the drug up to 24 h. It reached a steady state after the third administration in multiple dosing. 6. Although further studies are necessary, these results indicate that a single oral dose of CZ could be used as an anticoccidial for laying hens due to the lack of residues in eggs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetonitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Albumins,
http://linkedlifedata.com/resource/pubmed/chemical/Coccidiostats,
http://linkedlifedata.com/resource/pubmed/chemical/Triazines,
http://linkedlifedata.com/resource/pubmed/chemical/clazuril
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1466-1799
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
609-18
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pubmed:meshHeading |
pubmed-meshheading:18836908-Acetonitriles,
pubmed-meshheading:18836908-Albumins,
pubmed-meshheading:18836908-Animal Feed,
pubmed-meshheading:18836908-Animals,
pubmed-meshheading:18836908-Area Under Curve,
pubmed-meshheading:18836908-Chickens,
pubmed-meshheading:18836908-Chromatography, High Pressure Liquid,
pubmed-meshheading:18836908-Coccidiostats,
pubmed-meshheading:18836908-Drug Administration Schedule,
pubmed-meshheading:18836908-Drug Residues,
pubmed-meshheading:18836908-Egg Yolk,
pubmed-meshheading:18836908-Eggs,
pubmed-meshheading:18836908-Female,
pubmed-meshheading:18836908-Half-Life,
pubmed-meshheading:18836908-Molecular Structure,
pubmed-meshheading:18836908-Reproducibility of Results,
pubmed-meshheading:18836908-Triazines
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pubmed:year |
2008
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pubmed:articleTitle |
Pharmacokinetic study of clazuril (Appertex) in eggs and plasma from laying hens after single or multiple treatments, using a new HPLC method for detection.
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pubmed:affiliation |
Section of Pharmacology and Toxicology, Department of Veterinary Clinics, Pisa, Italy. mgiorgi@vet.unipi.it
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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