Linked Life Data

18836313

Source:http://linkedlifedata.com/resource/pubmed/id/18836313

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-10-6
pubmed:abstractText
Cell competition was first described in imaginal discs of genetically-mosaic Drosophila. In extreme cases, cell competition can replace entire compartments with the descendents of a single cell. We recently identified five genes that are required by wild-type epithelial cells to kill neighboring Minute cells during cell competition. These draper, wasp, phosphatidyl-serine receptor, MBC/DOCK180 and Rac1 genes, were each previously implicated in the engulfment of apoptotic corpses. The results draw attention to the active, killing role of engulfing cells during cell competition. Here we discuss the contributions of these engulfment genes to Minute competition in more detail, and compare Minute competition with competition between cells expressing different levels of Myc, or of Warts pathway genes. We also speculate about how cell interactions at clone boundaries may initiate cell competition.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1933-6942
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
274-8
pubmed:dateRevised
2009-3-27
pubmed:meshHeading
pubmed:articleTitle
The active role of corpse engulfment pathways during cell competition.
pubmed:affiliation
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural