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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2009-10-30
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pubmed:abstractText |
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3beta.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AlbertiJennifer BJB,
pubmed-author:DavisStephen TST,
pubmed-author:GriffinRobert JRJ,
pubmed-author:HassellAnne MAM,
pubmed-author:Kane-CarsonLaurie SLS,
pubmed-author:KnickVictoria BVB,
pubmed-author:PeelMichael RMR,
pubmed-author:PriceDaniel JDJ,
pubmed-author:RenoMichael JMJ,
pubmed-author:ShewchukLisa MLM,
pubmed-author:StevensKirk LKL,
pubmed-author:VealJames MJM
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5758-62
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:18835709-Cyclin-Dependent Kinase 4,
pubmed-meshheading:18835709-Drug Evaluation, Preclinical,
pubmed-meshheading:18835709-Drug Screening Assays, Antitumor,
pubmed-meshheading:18835709-Glycogen Synthase Kinase 3,
pubmed-meshheading:18835709-Models, Molecular,
pubmed-meshheading:18835709-Protein Kinase Inhibitors,
pubmed-meshheading:18835709-Pyridazines,
pubmed-meshheading:18835709-Vascular Endothelial Growth Factor Receptor-2
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
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pubmed:affiliation |
Department of Oncology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. Kirk.L.Stevens@gsk.com
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pubmed:publicationType |
Journal Article
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