Source:http://linkedlifedata.com/resource/pubmed/id/18834635
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2008-11-21
|
| pubmed:abstractText |
Serological diagnosis of human brucellosis is problematic in endemic brucellosis regions and with patients having a history of brucellosis. The aim of this study is to ascertain the serologic and evolutionary behavior of the tests of serum agglutination, Coombs anti-Brucella, immunocapture-agglutination, enzyme-linked immunosorbent assay (ELISA) IgG, IgA, IgM and ELISA-IgG avidity against Brucella lipopolysaccharide (S-LPS), in patients with acute brucellosis based on whether or not a history of brucellosis exists. Titers and seropositivity in all the tests assayed were higher in the patients having brucellosis history (from 90.9% in ELISA-IgM to 100% in ELISA-IgG) than in the patients lacking such history (from 79.3% in ELISA-IgM to 86.2% in Coombs, immunocapture-agglutination, and ELISA-IgG). IgG S-LPS avidity results in patients with brucellosis history were significantly higher (always over 84%) than in patients without brucellosis history (from 48.0% in the initial sera to 81% ten months later) (p<0.001). The titers of antibodies against Brucella in the initial sera and ELISA-IgG avidity against S-LPS may allow distinguishing patients with brucellosis caused by primary infection in the initial stages of the disease from patients seropositive due to prior infections from Brucella.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1532-2742
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| pubmed:author |
pubmed-author:AlmarazAnaA,
pubmed-author:BratosMiguel AngelMA,
pubmed-author:ColmeneroJuan de DiosJde D,
pubmed-author:CuberoAfricaA,
pubmed-author:Fernández-LagoLuisL,
pubmed-author:GutiérrezMaría PurificaciónMP,
pubmed-author:MantecónMaría de Los AngelesMde L,
pubmed-author:MuñozMaria FeMF,
pubmed-author:OrduñaAntonioA,
pubmed-author:Rodríguez TorresAA,
pubmed-author:VizcaínoNievesN,
pubmed-author:ZarzosaMaría Del PilarMdel P
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
397-403
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| pubmed:meshHeading |
pubmed-meshheading:18834635-Acute Disease,
pubmed-meshheading:18834635-Adolescent,
pubmed-meshheading:18834635-Adult,
pubmed-meshheading:18834635-Aged,
pubmed-meshheading:18834635-Agglutination Tests,
pubmed-meshheading:18834635-Antibodies, Bacterial,
pubmed-meshheading:18834635-Brucella,
pubmed-meshheading:18834635-Brucellosis,
pubmed-meshheading:18834635-Child,
pubmed-meshheading:18834635-Coombs' Test,
pubmed-meshheading:18834635-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18834635-Female,
pubmed-meshheading:18834635-Humans,
pubmed-meshheading:18834635-Male,
pubmed-meshheading:18834635-Middle Aged,
pubmed-meshheading:18834635-Recurrence,
pubmed-meshheading:18834635-Serologic Tests,
pubmed-meshheading:18834635-Young Adult
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Influence of brucellosis history on serological diagnosis and evolution of patients with acute brucellosis.
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| pubmed:affiliation |
Unidad de Investigación, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|