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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-10-6
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pubmed:abstractText |
Genetic polymorphism of CYP2D6 leads to differences in pharmacokinetics of CYP2D6 substrates. The CYP2D6*10 allele is clinically important in Koreans because of its high frequency in Asians. We investigated whether the pharmacokinetics of metoprolol was altered by the presence of the CYP2D6*10 allele in Korean subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1365-2710
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
567-73
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pubmed:meshHeading |
pubmed-meshheading:18834373-Administration, Oral,
pubmed-meshheading:18834373-Adrenergic beta-Antagonists,
pubmed-meshheading:18834373-Adult,
pubmed-meshheading:18834373-Alleles,
pubmed-meshheading:18834373-Area Under Curve,
pubmed-meshheading:18834373-Asian Continental Ancestry Group,
pubmed-meshheading:18834373-Cytochrome P-450 CYP2D6,
pubmed-meshheading:18834373-Female,
pubmed-meshheading:18834373-Half-Life,
pubmed-meshheading:18834373-Humans,
pubmed-meshheading:18834373-Korea,
pubmed-meshheading:18834373-Male,
pubmed-meshheading:18834373-Metoprolol,
pubmed-meshheading:18834373-Pharmacogenetics,
pubmed-meshheading:18834373-Polymorphism, Genetic,
pubmed-meshheading:18834373-Young Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers.
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pubmed:affiliation |
Department of Pharmacological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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