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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-10-6
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pubmed:abstractText |
Topiramate was approved for the treatment of epilepsy in 1999 and has since been approved for the prevention of migraine headache. It is structurally different from the majority of antiepileptic medications and is pharmacodynamically unique in its ability to inhibit the enzyme carbonic anhydrase. Postmarketing reports of topiramate-associated hypothermia have occurred but this adverse event has not been well characterized. Data mining of an adverse event database was used to assist in the identification of hypothermia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1365-2710
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
513-9
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pubmed:meshHeading |
pubmed-meshheading:18834366-Adolescent,
pubmed-meshheading:18834366-Adult,
pubmed-meshheading:18834366-Adverse Drug Reaction Reporting Systems,
pubmed-meshheading:18834366-Aged,
pubmed-meshheading:18834366-Aged, 80 and over,
pubmed-meshheading:18834366-Algorithms,
pubmed-meshheading:18834366-Ammonia,
pubmed-meshheading:18834366-Anticonvulsants,
pubmed-meshheading:18834366-Bicarbonates,
pubmed-meshheading:18834366-Child,
pubmed-meshheading:18834366-Child, Preschool,
pubmed-meshheading:18834366-Databases, Factual,
pubmed-meshheading:18834366-Drug Interactions,
pubmed-meshheading:18834366-Female,
pubmed-meshheading:18834366-Fructose,
pubmed-meshheading:18834366-Humans,
pubmed-meshheading:18834366-Hypothermia,
pubmed-meshheading:18834366-Male,
pubmed-meshheading:18834366-Middle Aged,
pubmed-meshheading:18834366-Retrospective Studies,
pubmed-meshheading:18834366-United States,
pubmed-meshheading:18834366-United States Food and Drug Administration,
pubmed-meshheading:18834366-Valproic Acid,
pubmed-meshheading:18834366-Young Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy.
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pubmed:affiliation |
New Hope Cancer Center, Hudson, FL, USA. james.knudsen@fda.hhs.gov
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pubmed:publicationType |
Journal Article
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