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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
8
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pubmed:dateCreated |
2008-10-3
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|
pubmed:abstractText |
There is controversy on the role of IgM memory and switched memory B lymphocytes in the Ab response to T cell-independent and T cell-dependent Ags. We transplanted SCID/SCID mice with human B lymphocyte subsets and immunized them with heat-inactivated Streptococcus pneumoniae or with a pneumococcal vaccine. Inactivated S. pneumoniae and soluble pneumococcal capsular polysaccharides elicited an IgM anti-polysaccharide and anti-protein Ab response from IgM memory B lymphocytes and an IgG anti-polysaccharide and anti-protein response from switched memory B lymphocytes. In addition to the IgM Ab response, IgM memory B cells elicited an IgG anti-polysaccharide and anti-protein Ab response after immunization with inactivated S. pneumoniae or soluble pneumococcal capsular polysaccharides. In conclusion, our findings provide evidence for a versatile role of IgM memory B cells in T-independent and T-dependent immune responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1550-6606
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
181
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
5306-12
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pubmed:meshHeading |
pubmed-meshheading:18832686-Animals,
pubmed-meshheading:18832686-Antibodies, Bacterial,
pubmed-meshheading:18832686-Antibody Formation,
pubmed-meshheading:18832686-Antigens, Bacterial,
pubmed-meshheading:18832686-B-Lymphocyte Subsets,
pubmed-meshheading:18832686-Bacterial Proteins,
pubmed-meshheading:18832686-Humans,
pubmed-meshheading:18832686-Immunization,
pubmed-meshheading:18832686-Immunoglobulin G,
pubmed-meshheading:18832686-Immunoglobulin M,
pubmed-meshheading:18832686-Immunologic Memory,
pubmed-meshheading:18832686-Mice,
pubmed-meshheading:18832686-Mice, Inbred BALB C,
pubmed-meshheading:18832686-Mice, SCID,
pubmed-meshheading:18832686-Pneumococcal Vaccines,
pubmed-meshheading:18832686-Polysaccharides, Bacterial,
pubmed-meshheading:18832686-Streptococcus pneumoniae,
pubmed-meshheading:18832686-T-Lymphocytes
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pubmed:year |
2008
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|
pubmed:articleTitle |
Human memory B lymphocyte subsets fulfill distinct roles in the anti-polysaccharide and anti-protein immune response.
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|
pubmed:affiliation |
Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Group Biomedical Sciences, Catholic University, Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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