Source:http://linkedlifedata.com/resource/pubmed/id/18832011
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
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| pubmed:dateCreated |
2009-1-28
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| pubmed:abstractText |
Despite continuing efforts to determine genetic vulnerability to panic disorder (PD), the studies of candidate genes in this disorder have produced inconsistent or negative, results. Laboratory panic induction may have a potential in testing genetic substrate of PD. In this study we aimed to explore the effects of several genetic polymorphisms previously implicated in PD on the susceptibility to cholecystokinin-tetrapeptide (CCK-4) challenge in healthy subjects. The study sample consisted of 110 healthy volunteers (47 males and 63 females, mean age 22.2 +/- 5.2) who participated in CCK-4 challenge test. Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic association studies in PD. After CCK-4 challenge, 39 (35.5%) subjects experienced a panic attack, while 71 subjects were defined as non-panickers. We detected significant differences for both genotypic and allelic frequencies of 1386494A/G polymorphism in TPH2 gene between panic and non-panic groups with the frequencies of G/G genotype and G allele significantly higher in panickers. None of the other candidate loci were significantly associated with CCK-4-induced panic attacks in healthy subjects. In line with our previous association study in patients with PD, we detected a possible association between TPH2 rs1386494 polymorphism and susceptibility to panic attacks. Other polymorphisms previously associated with PD were unrelated to CCK-4-induced panic attacks, probably due to the differences between complex nature of PD and laboratory panic model.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0304-3940
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
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| pubmed:volume |
446
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
88-92
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:18832011-Adult,
pubmed-meshheading:18832011-Brain,
pubmed-meshheading:18832011-Brain Chemistry,
pubmed-meshheading:18832011-Catecholamines,
pubmed-meshheading:18832011-DNA Mutational Analysis,
pubmed-meshheading:18832011-Female,
pubmed-meshheading:18832011-Gene Frequency,
pubmed-meshheading:18832011-Genetic Predisposition to Disease,
pubmed-meshheading:18832011-Genetic Testing,
pubmed-meshheading:18832011-Genotype,
pubmed-meshheading:18832011-Humans,
pubmed-meshheading:18832011-Male,
pubmed-meshheading:18832011-Mutation,
pubmed-meshheading:18832011-Panic Disorder,
pubmed-meshheading:18832011-Polymorphism, Genetic,
pubmed-meshheading:18832011-Tetragastrin,
pubmed-meshheading:18832011-Tryptophan Hydroxylase,
pubmed-meshheading:18832011-Young Adult
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Association testing of panic disorder candidate genes using CCK-4 challenge in healthy volunteers.
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| pubmed:affiliation |
Department of Psychiatry, University of Tartu, Tartu, Estonia. Eduard.Maron@kliinikum.ee
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|