Linked Life Data

18830919

Source:http://linkedlifedata.com/resource/pubmed/id/18830919

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-10-2
pubmed:abstractText
Despite various obstacles the promise of gene therapy has begun to be realized, as demonstrated by the successful phenotypic correction of X-linked SCID in infants. Although ex vivo gene therapy is advantageous, many diseases, for example, disseminated cancers, require intravascular administration of the gene therapy vector in vivo. In this scenario, the development of sophisticated vectors suitable for targeted intravascular gene delivery is required to both improve efficacy and minimize toxicity. Vectors based on adenovirus (Ad) show immense promise because they are highly efficient in transducing non-dividing cells, can tolerate substantial genetic manipulation (eg, the incorporation of targeting agents), can be produced to high titer, do not integrate into the genome, and have undergone significant investigation in the clinic. However, the use of Ad-based vectors is limited by the inherent hepatic tropism of intravascularly administered Ad, which precludes targeted delivery to alternative organs or disease sites, and by the associated host inflammatory responses to the vector. An improved knowledge of the complex series of interactions is of fundamental importance to the field. This review discusses the current understanding of Ad vector and host interactions, as well as suitable technologies for optimizing delivery to target cells in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1464-8431
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
439-48
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications.
pubmed:affiliation
University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, Glasgow, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't