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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2008-10-2
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pubmed:abstractText |
Aberrant promoter methylation and genomic instability occur frequently during colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown to associate with microsatellite instability, and BRAF mutation and is often found in the right-side colon. Nevertheless, the relative importance of CIMP and chromosomal instability (CIN) for tumorigenesis has yet to be thoroughly investigated in sporadic colorectal cancers.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BacolodManny DMD,
pubmed-author:BaranyFrancisF,
pubmed-author:BarralSandraS,
pubmed-author:ChengYu-WeiYW,
pubmed-author:GiardinaSarah FSF,
pubmed-author:HuangJianminJ,
pubmed-author:IdreesKamranK,
pubmed-author:KhanSajid ASA,
pubmed-author:NottermanDaniel ADA,
pubmed-author:OttJurgJ,
pubmed-author:PatyPhilipP,
pubmed-author:PincasHannaH,
pubmed-author:RosenbergShoshanaS,
pubmed-author:SchemmannGunterG,
pubmed-author:ZengZhaoshiZ
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6005-13
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18829479-Chromosomal Instability,
pubmed-meshheading:18829479-Chromosome Aberrations,
pubmed-meshheading:18829479-Colorectal Neoplasms,
pubmed-meshheading:18829479-CpG Islands,
pubmed-meshheading:18829479-DNA Methylation,
pubmed-meshheading:18829479-Epigenesis, Genetic,
pubmed-meshheading:18829479-Female,
pubmed-meshheading:18829479-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18829479-Genome, Human,
pubmed-meshheading:18829479-Humans,
pubmed-meshheading:18829479-Male,
pubmed-meshheading:18829479-Microsatellite Repeats,
pubmed-meshheading:18829479-Mutation,
pubmed-meshheading:18829479-Phenotype,
pubmed-meshheading:18829479-Proto-Oncogene Proteins B-raf
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pubmed:year |
2008
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pubmed:articleTitle |
CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer.
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pubmed:affiliation |
Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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