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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1991-10-3
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pubmed:abstractText |
We reviewed the course of 54 patients who had unilateral acute retinal necrosis at initial examination. Thirty-one patients were treated with acyclovir, whereas 23 were not. Of the 31 patients treated with acyclovir, 27 (87.1%) had fellow eyes that remained disease-free throughout a median follow-up of 12 months. Of the 23 patients not treated with acyclovir, seven (30.4%) had fellow eyes that remained disease-free throughout a median follow-up of 11 months. Survival analysis indicated that the fellow eyes of the group of patients treated with acyclovir were more likely to remain disease-free than the fellow eyes of the group not treated with acyclovir (P = .0013). Two years after initial onset, the proportion of fellow eyes that remained disease-free was 75.3% for the group treated with acyclovir and 35.1% for the group not treated with acyclovir. These results suggest that acyclovir treatment reduces the risk of involvement of the fellow eye in patients with acute retinal necrosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0002-9394
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
112
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
250-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1882936-Acyclovir,
pubmed-meshheading:1882936-Adolescent,
pubmed-meshheading:1882936-Adult,
pubmed-meshheading:1882936-Drug Administration Routes,
pubmed-meshheading:1882936-Female,
pubmed-meshheading:1882936-Follow-Up Studies,
pubmed-meshheading:1882936-Humans,
pubmed-meshheading:1882936-Male,
pubmed-meshheading:1882936-Middle Aged,
pubmed-meshheading:1882936-Retinal Necrosis Syndrome, Acute,
pubmed-meshheading:1882936-Risk Factors,
pubmed-meshheading:1882936-Survival Analysis
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pubmed:year |
1991
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pubmed:articleTitle |
Decrease in the risk of bilateral acute retinal necrosis by acyclovir therapy.
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pubmed:affiliation |
Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|