Linked Life Data

18829315

Source:http://linkedlifedata.com/resource/pubmed/id/18829315

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2008-10-20
pubmed:abstractText
Several novel catechin/epicatechin and nucleobase chimeric molecules 1-6 have been synthesized via azide-alkyne click chemistry. The structures of these hybrids have been confirmed by NMR and mass spectroscopic data. The synthesized molecules were tested for their RNase A inhibition activities. Gel-based assays showed inhibition in micromolar concentrations. The extent of inhibition was found to be dependent upon the nature of base as well as the configuration at C-3 position of catechin.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5411-4
pubmed:dateRevised
2009-8-28
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Design, synthesis and RNase A inhibition activity of catechin and epicatechin and nucleobase chimeric molecules.
pubmed:affiliation
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't