Linked Life Data

18826756

Source:http://linkedlifedata.com/resource/pubmed/id/18826756

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-6-10
pubmed:abstractText
The relationship between neurogenesis and epilepsy remains to be solved so far, although aberrant electric circuit recognized in epilepsy might be involved in neurogenesis. In this study, neurogenesis and the proliferation of astrocytes in the subgranular zone of the hippocampus were explored using unilateral amygdala-kindled rats with or without muscimol, a gamma-aminobutyric acid a (GABAa) agonist injection into the bilateral anterior thalamic nuclei (AN). Muscimol injection significantly ameliorated the behavioral scores of epilepsy without any significant alteration on the electroencephalography recorded at the stimulated basolateral amygdala, thus suggesting that muscimol injection might affect the secondary generalization, but not the initial discharge itself. The number of bromodeoxyuridine (BrdU), BrdU/doublecortin and BrdU/glial fibrillary acidic protein-positive cells in the subgranular zone of kindled animals increased markedly. Muscimol injection significantly suppressed neurogenesis, but not the proliferation of astrocyte, in the subgranular zone of the non-stimulated side, probably through the suppression of secondary generalization via AN. The results might indicate the underlying relationships between neurogenesis and epilepsy, that epileptic propagation in unilateral amygdala-kindled rats might go through AN into the contralateral side with subsequent neurogenesis, although further studies need to clarify the hypothesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0161-6412
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
407-13
pubmed:meshHeading
pubmed-meshheading:18826756-Amygdala, pubmed-meshheading:18826756-Animals, pubmed-meshheading:18826756-Anterior Thalamic Nuclei, pubmed-meshheading:18826756-Bromodeoxyuridine, pubmed-meshheading:18826756-Cell Count, pubmed-meshheading:18826756-Cell Differentiation, pubmed-meshheading:18826756-Cell Proliferation, pubmed-meshheading:18826756-Disease Models, Animal, pubmed-meshheading:18826756-Electric Stimulation, pubmed-meshheading:18826756-Electroencephalography, pubmed-meshheading:18826756-Epilepsy, pubmed-meshheading:18826756-Functional Laterality, pubmed-meshheading:18826756-GABA Agonists, pubmed-meshheading:18826756-Glial Fibrillary Acidic Protein, pubmed-meshheading:18826756-Hippocampus, pubmed-meshheading:18826756-Indoles, pubmed-meshheading:18826756-Kindling, Neurologic, pubmed-meshheading:18826756-Male, pubmed-meshheading:18826756-Microtubule-Associated Proteins, pubmed-meshheading:18826756-Muscimol, pubmed-meshheading:18826756-Neurogenesis, pubmed-meshheading:18826756-Neuropeptides, pubmed-meshheading:18826756-Rats, pubmed-meshheading:18826756-Rats, Sprague-Dawley
pubmed:year
2009
pubmed:articleTitle
Injection of muscimol, a GABAa agonist into the anterior thalamic nucleus, suppresses hippocampal neurogenesis in amygdala-kindled rats.
pubmed:affiliation
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't