|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-2-11
|
|
pubmed:abstractText |
Immune thrombocytopenic purpura (ITP) is an autoimmune disease primarily caused by IgG anti-platelet autoantibodies. Activation of autoreactive CD4(+) T cells upon recognition of cryptic GPIIb/IIIa peptides presented by antigen-presenting cells (APCs) is a critical step for triggering and maintaining the pathogenic anti-platelet autoantibody response.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1538-7836
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
322-9
|
|
pubmed:meshHeading |
pubmed-meshheading:18826388-Antigen Presentation,
pubmed-meshheading:18826388-Antigen-Presenting Cells,
pubmed-meshheading:18826388-Autoimmunity,
pubmed-meshheading:18826388-B-Lymphocytes,
pubmed-meshheading:18826388-Blood Platelets,
pubmed-meshheading:18826388-Cells, Cultured,
pubmed-meshheading:18826388-Coculture Techniques,
pubmed-meshheading:18826388-Dendritic Cells,
pubmed-meshheading:18826388-Humans,
pubmed-meshheading:18826388-Macrophages,
pubmed-meshheading:18826388-Opsonin Proteins,
pubmed-meshheading:18826388-Platelet Glycoprotein GPIIb-IIIa Complex,
pubmed-meshheading:18826388-Purpura, Thrombocytopenic, Idiopathic,
pubmed-meshheading:18826388-Receptors, IgG,
pubmed-meshheading:18826388-Spleen,
pubmed-meshheading:18826388-T-Lymphocytes
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Splenic macrophages maintain the anti-platelet autoimmune response via uptake of opsonized platelets in patients with immune thrombocytopenic purpura.
|
|
pubmed:affiliation |
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. kuwanam@sc.itc.keio.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
