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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-10-1
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pubmed:abstractText |
In their previous studies, the authors found that simvastatin treatment of traumatic brain injury (TBI) in rats had beneficial effects on spatial learning functions. In the current study they wanted to determine whether simvastatin suppressed neuronal cell apoptosis after TBI, and if so, they wanted to examine the underlying mechanisms of this process.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxo1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
691-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18826357-Animals,
pubmed-meshheading:18826357-Apoptosis,
pubmed-meshheading:18826357-Brain Injuries,
pubmed-meshheading:18826357-Cell Survival,
pubmed-meshheading:18826357-Forkhead Transcription Factors,
pubmed-meshheading:18826357-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:18826357-I-kappa B Proteins,
pubmed-meshheading:18826357-In Situ Nick-End Labeling,
pubmed-meshheading:18826357-Male,
pubmed-meshheading:18826357-Nerve Tissue Proteins,
pubmed-meshheading:18826357-Neurons,
pubmed-meshheading:18826357-Nitric Oxide Synthase Type II,
pubmed-meshheading:18826357-Nitric Oxide Synthase Type III,
pubmed-meshheading:18826357-Phosphorylation,
pubmed-meshheading:18826357-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18826357-Rats,
pubmed-meshheading:18826357-Rats, Wistar,
pubmed-meshheading:18826357-Recovery of Function,
pubmed-meshheading:18826357-Signal Transduction,
pubmed-meshheading:18826357-Simvastatin,
pubmed-meshheading:18826357-Trauma Severity Indices
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pubmed:year |
2008
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pubmed:articleTitle |
Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury.
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pubmed:affiliation |
Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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