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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-10-24
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pubmed:abstractText |
Four new partially acylated tetrasaccharides of 11-hydroxyhexadecanoic acid (1-4) were isolated from a methanolic extract of Ipomoea tyrianthina. The structures of these compounds were elucidated by spectroscopic and chemical methods. The resin glycoside composition of I. tyrianthina varied with the location of growth in Mexico. Compounds 1-4 showed antimycobacterial activity, were cytotoxic against the KB cell line, and, in a mouse model, exhibited potentiation of hypnosis induced by pentobarbital, protected against seizures induced by pentylenetetrazole, and released GABA and glutamic acid.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1520-6025
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1686-91
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pubmed:meshHeading |
pubmed-meshheading:18826278-Animals,
pubmed-meshheading:18826278-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:18826278-Antitubercular Agents,
pubmed-meshheading:18826278-Central Nervous System,
pubmed-meshheading:18826278-Glutamic Acid,
pubmed-meshheading:18826278-Humans,
pubmed-meshheading:18826278-Ipomoea,
pubmed-meshheading:18826278-KB Cells,
pubmed-meshheading:18826278-Mexico,
pubmed-meshheading:18826278-Mice,
pubmed-meshheading:18826278-Models, Animal,
pubmed-meshheading:18826278-Oligosaccharides,
pubmed-meshheading:18826278-Pentobarbital,
pubmed-meshheading:18826278-Pentylenetetrazole,
pubmed-meshheading:18826278-Plant Roots,
pubmed-meshheading:18826278-Plants, Medicinal,
pubmed-meshheading:18826278-Tuberculosis,
pubmed-meshheading:18826278-gamma-Aminobutyric Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Tyrianthinic acids from Ipomoea tyrianthina and their antimycobacterial activity, cytotoxicity, and effects on the central nervous system.
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pubmed:affiliation |
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Mexico. ismaelr@ciq.uaem.mx
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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