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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14 Suppl
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pubmed:dateCreated |
2008-9-30
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pubmed:abstractText |
Clinical outcome of surgical revascularization using autologous vein graft is limited by vein graft failure attributable to neointima formation. Platelet-derived growth factor (PDGF) plays a central role in the pathogenesis of vein graft failure. Therefore, we hypothesized that nanoparticle (NP)-mediated drug delivery system of PDGF-receptor (PDGF-R) tyrosine kinase inhibitor (imatinib mesylate: STI571) could be an innovative therapeutic strategy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S65-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18824771-Animals,
pubmed-meshheading:18824771-Aorta,
pubmed-meshheading:18824771-Cell Movement,
pubmed-meshheading:18824771-Cell Proliferation,
pubmed-meshheading:18824771-Cells, Cultured,
pubmed-meshheading:18824771-Coronary Vessels,
pubmed-meshheading:18824771-Drug Delivery Systems,
pubmed-meshheading:18824771-Humans,
pubmed-meshheading:18824771-Intracellular Membranes,
pubmed-meshheading:18824771-Jugular Veins,
pubmed-meshheading:18824771-Male,
pubmed-meshheading:18824771-Muscle, Smooth, Vascular,
pubmed-meshheading:18824771-Myocytes, Smooth Muscle,
pubmed-meshheading:18824771-Nanoparticles,
pubmed-meshheading:18824771-Phosphorylation,
pubmed-meshheading:18824771-Piperazines,
pubmed-meshheading:18824771-Protein Kinase Inhibitors,
pubmed-meshheading:18824771-Pyrimidines,
pubmed-meshheading:18824771-Rabbits,
pubmed-meshheading:18824771-Rats,
pubmed-meshheading:18824771-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:18824771-Tissue Distribution,
pubmed-meshheading:18824771-Tunica Intima
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pubmed:year |
2008
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pubmed:articleTitle |
Local delivery of imatinib mesylate (STI571)-incorporated nanoparticle ex vivo suppresses vein graft neointima formation.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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