Linked Life Data

18824070

Source:http://linkedlifedata.com/resource/pubmed/id/18824070

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2009-1-28
pubmed:abstractText
Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are characterized by T cell-mediated autoimmune inflammation of the central nervous system (CNS) leading to oligodendrocyte loss and demyelination accompanied by neuronal cell death. Neuronal TWIK-related acid-sensitive potassium (TASK) channels allow the regulated efflux of potassium ions. These channels might either protect neurons in the inflamed CNS by modulating electrical excitability or even contribute to inflammatory neurodegeneration mediating intracellular potassium depletion. Using a combination of in-situ-hybridisation and immunofluorescence staining, we found increased neuronal expression of TASK1 and TASK3 channels in the optic nerve and decreased expression in the spinal cord and thalamus of rats undergoing MOG-induced EAE. Inflammatory plaques of human MS patients displayed profoundly lowered expression of both TASK isoforms. Thus, regulated expression of TASK channels might contribute to a molecular switch between death and survival of neurons in autoimmune CNS inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
446
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-8
pubmed:meshHeading
pubmed-meshheading:18824070-Animals, pubmed-meshheading:18824070-Cell Survival, pubmed-meshheading:18824070-Central Nervous System, pubmed-meshheading:18824070-Disease Models, Animal, pubmed-meshheading:18824070-Encephalomyelitis, Autoimmune, Experimental, pubmed-meshheading:18824070-Fluorescent Antibody Technique, pubmed-meshheading:18824070-Humans, pubmed-meshheading:18824070-In Situ Hybridization, pubmed-meshheading:18824070-Multiple Sclerosis, pubmed-meshheading:18824070-Nerve Tissue Proteins, pubmed-meshheading:18824070-Neurons, pubmed-meshheading:18824070-Optic Nerve, pubmed-meshheading:18824070-Potassium, pubmed-meshheading:18824070-Potassium Channels, Tandem Pore Domain, pubmed-meshheading:18824070-Rats, pubmed-meshheading:18824070-Spinal Cord, pubmed-meshheading:18824070-Thalamus
pubmed:year
2008
pubmed:articleTitle
Altered neuronal expression of TASK1 and TASK3 potassium channels in rodent and human autoimmune CNS inflammation.
pubmed:affiliation
Department of Neurology, University of Würzburg, Josef-Schneider-Strafe 11, 97080 Würzburg, Germany. meuth_s@klinik.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't