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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2009-1-28
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pubmed:abstractText |
Massive neuronal activation by glutamate can result in an excessive rise in cytoplasmic calcium, a process ultimately leading to neuronal death. We have investigated the role of the transient receptor potential channel 1 (TRPC1) in mediating glutamate-induced neuron death. We show that 2-APB (a blocker of store-operated Ca2+ entry) dramatically reduces glutamate-induced cell death in hippocampal organotypic slice cultures and that glutamate-induced toxicity is accompanied by an increase in TRPC1 expression. RNAi mediated knock-down ofTRPC1 in slice cultures prevented glutamate-induced cell death, indicating that TRPC1 plays a prominent role in calcium entry following exposure to glutamate. Thus, TRPC1 may represent a promising target for pharmacological interventions to prevent or reduce glutamate-induced neuronal damage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
446
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-22
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pubmed:meshHeading |
pubmed-meshheading:18822346-Animals,
pubmed-meshheading:18822346-Animals, Newborn,
pubmed-meshheading:18822346-Atrophy,
pubmed-meshheading:18822346-Boron Compounds,
pubmed-meshheading:18822346-Calcium,
pubmed-meshheading:18822346-Calcium Signaling,
pubmed-meshheading:18822346-Cell Death,
pubmed-meshheading:18822346-Down-Regulation,
pubmed-meshheading:18822346-Glutamic Acid,
pubmed-meshheading:18822346-Hippocampus,
pubmed-meshheading:18822346-Mice,
pubmed-meshheading:18822346-Mice, Inbred C57BL,
pubmed-meshheading:18822346-Nerve Degeneration,
pubmed-meshheading:18822346-Neurodegenerative Diseases,
pubmed-meshheading:18822346-Neurons,
pubmed-meshheading:18822346-Neurotoxins,
pubmed-meshheading:18822346-Organ Culture Techniques,
pubmed-meshheading:18822346-RNA Interference,
pubmed-meshheading:18822346-TRPC Cation Channels
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pubmed:year |
2008
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pubmed:articleTitle |
Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death.
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pubmed:affiliation |
Interdisciplinary Centerfor Neurosciences (IZN), Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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