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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0018894,
umls-concept:C0024429,
umls-concept:C0041904,
umls-concept:C0162493,
umls-concept:C0224522,
umls-concept:C0242633,
umls-concept:C0312359,
umls-concept:C0623362,
umls-concept:C1334507,
umls-concept:C1423842,
umls-concept:C1704675
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pubmed:issue |
10
|
|
pubmed:dateCreated |
2008-10-9
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|
pubmed:abstractText |
Interactions of immune cells, such as activated T helper cells, with fibroblast-like synoviocytes (FLS) play a crucial role in the joint destruction during human rheumatoid arthritis (RA). This study was undertaken to investigate the expression of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) by T helper cells, and to assess the role of MIF in overexpression of matrix metalloproteinases (MMPs) in cocultures of FLS from arthritic mice with either Th1 or Th2 cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-3591
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3030-40
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pubmed:meshHeading |
pubmed-meshheading:18821693-Animals,
pubmed-meshheading:18821693-Arthritis, Experimental,
pubmed-meshheading:18821693-Arthritis, Rheumatoid,
pubmed-meshheading:18821693-Cells, Cultured,
pubmed-meshheading:18821693-Coculture Techniques,
pubmed-meshheading:18821693-Female,
pubmed-meshheading:18821693-Fibroblasts,
pubmed-meshheading:18821693-Intramolecular Oxidoreductases,
pubmed-meshheading:18821693-Knee Joint,
pubmed-meshheading:18821693-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:18821693-Matrix Metalloproteinases,
pubmed-meshheading:18821693-Mice,
pubmed-meshheading:18821693-Synovial Membrane,
pubmed-meshheading:18821693-Th1 Cells,
pubmed-meshheading:18821693-Th2 Cells,
pubmed-meshheading:18821693-Up-Regulation
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pubmed:year |
2008
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|
pubmed:articleTitle |
Interactions of T helper cells with fibroblast-like synoviocytes: up-regulation of matrix metalloproteinases by macrophage migration inhibitory factor from both Th1 and Th2 cells.
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pubmed:affiliation |
University Hospital Jena, Jena, Germany. uta.schurigt@uni-wuerzburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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