Source:http://linkedlifedata.com/resource/pubmed/id/18820807
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2008-9-29
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| pubmed:abstractText |
The present study was carried to develop and analyze the consequences of hypercaloric pellet-diet cycle that promotes obesity in rats. Male Wistar rats were randomly distributed into two groups that received either normal diet (ND; n =32; 3,5 Kcal/g) or a hypercaloric diet (HD; n =32; 4,6 Kcal/g). The ND group received commercial Labina rat feeding while the HD animals received a cycle of five hypercaloric diets over a 14-week period. The effects of the diets were analyzed in terms of body weight, body composition, hormone-metabolite levels, systolic arterial pressure and glucose tolerance at the 5% significance level. The hypercaloric pellet diet cycle promoted an increase in body weight and fat, systolic arterial pressure and a high serum level of glucose, triacylglycerol, insulin and leptin. The HD group also presented an impaired glucose tolerance. In conclusion, the results of this study show that the hypercaloric pellet-diet cycle promoted obesity in Wistar rats and displayed several characteristics that are commonly associated with human obesity, such as high arterial pressure, insulin resistance, hyperglycaemia, hyperinsulinaemia, hyperleptinaemia and dyslipidaemia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1677-9487
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
52
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
968-74
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| pubmed:meshHeading |
pubmed-meshheading:18820807-Analysis of Variance,
pubmed-meshheading:18820807-Animals,
pubmed-meshheading:18820807-Blood Pressure,
pubmed-meshheading:18820807-Body Composition,
pubmed-meshheading:18820807-Body Weight,
pubmed-meshheading:18820807-Dietary Fats,
pubmed-meshheading:18820807-Disease Models, Animal,
pubmed-meshheading:18820807-Dyslipidemias,
pubmed-meshheading:18820807-Energy Intake,
pubmed-meshheading:18820807-Humans,
pubmed-meshheading:18820807-Hyperglycemia,
pubmed-meshheading:18820807-Hyperinsulinism,
pubmed-meshheading:18820807-Hypertension,
pubmed-meshheading:18820807-Leptin,
pubmed-meshheading:18820807-Male,
pubmed-meshheading:18820807-Obesity,
pubmed-meshheading:18820807-Random Allocation,
pubmed-meshheading:18820807-Rats,
pubmed-meshheading:18820807-Rats, Wistar
|
| pubmed:year |
2008
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| pubmed:articleTitle |
A hypercaloric pellet-diet cycle induces obesity and co-morbidities in Wistar rats.
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| pubmed:affiliation |
Departamento de Clínica Médica e Laboratório Experimental da Clínica Médica da Faculdade de Medicina de Botucatu, Universidade Estadual Paulista.
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| pubmed:publicationType |
Journal Article
|