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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-9-30
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pubmed:abstractText |
The analgesic response (tail-flick latency) induced by the muscarinic cholinergic agonist oxotremorine was investigated in DBA/2 mice exposed to acute (a single 2 h session) and chronic (2 h once daily for 10 days) restraint stress. While a single exposure to stress did not influence the antinociceptive effects of the cholinergic agonist, chronic stress induced a clear-cut reduction of the oxotremorine-induced analgesia. The results show an involvement of cholinergic mechanisms in the adaptive modulation of nociception after chronic stressful events.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0033-3158
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1882004-Acute Disease,
pubmed-meshheading:1882004-Analgesics,
pubmed-meshheading:1882004-Animals,
pubmed-meshheading:1882004-Chronic Disease,
pubmed-meshheading:1882004-Mice,
pubmed-meshheading:1882004-Mice, Inbred DBA,
pubmed-meshheading:1882004-Motor Activity,
pubmed-meshheading:1882004-Oxotremorine,
pubmed-meshheading:1882004-Reaction Time,
pubmed-meshheading:1882004-Restraint, Physical,
pubmed-meshheading:1882004-Stress, Psychological
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pubmed:year |
1991
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pubmed:articleTitle |
Reduction of oxotremorine-induced analgesia after chronic but not acute restraint stress.
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pubmed:affiliation |
Istituto di Psicobiologia e Psicofarmacologia del C.N.R., Roma, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study
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