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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1991-10-3
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pubmed:abstractText |
A polyclonal antiserum directed against the C-terminal domain of dystrophin was used to isolate a cDNA clone encoding an antigenically cross-reactive protein, microtubule-associated protein 1B (MAP-1B). Physical mapping of the human MAP-1B locus places its chromosomal location at 5q13, in proximity to the spinal muscular atrophy (SMA) locus. SMA is a degenerative disorder primarily affecting motor neurons. Genetic linkage analysis of SMA families using a human dinucleotide repeat polymorphism just 3' of the MAP-1B gene has shown tight linkage to SMA mutations. These mapping data together with the postulated role of MAP-1B in neuronal morphogenesis and its localization in anterior horn motor neurons suggest a possible association with SMA.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-1970420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-1972783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-1998344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2037303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2247230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2259381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2294592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2320125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2407739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2480963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2507752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2541343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2562784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2624748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2645301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2648158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2668783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2675425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2677025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2684423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-2981859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-3287171,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-3319190,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-3385011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-3659917,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1881920-6587361
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7873-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1881920-Animals,
pubmed-meshheading:1881920-Base Sequence,
pubmed-meshheading:1881920-Brain,
pubmed-meshheading:1881920-Chromosome Mapping,
pubmed-meshheading:1881920-Chromosomes, Human, Pair 5,
pubmed-meshheading:1881920-Dystrophin,
pubmed-meshheading:1881920-Female,
pubmed-meshheading:1881920-Genetic Linkage,
pubmed-meshheading:1881920-Humans,
pubmed-meshheading:1881920-Male,
pubmed-meshheading:1881920-Mice,
pubmed-meshheading:1881920-Mice, Mutant Strains,
pubmed-meshheading:1881920-Microtubule-Associated Proteins,
pubmed-meshheading:1881920-Molecular Sequence Data,
pubmed-meshheading:1881920-Muscles,
pubmed-meshheading:1881920-Muscular Atrophy, Spinal,
pubmed-meshheading:1881920-Muscular Dystrophy, Animal,
pubmed-meshheading:1881920-Oligonucleotide Probes,
pubmed-meshheading:1881920-Pedigree,
pubmed-meshheading:1881920-Reference Values
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pubmed:year |
1991
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pubmed:articleTitle |
Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13.
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pubmed:affiliation |
Department of Genetics, Harvard Medical School, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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