| pubmed-article:18819071 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C1420610 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18819071 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18819071 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:18819071 | pubmed:dateCreated | 2008-10-1 | lld:pubmed |
| pubmed-article:18819071 | pubmed:abstractText | By cross-linking B7-DC on dendritic cells (DC) the human IgM antibody (B7-DC XAb) shifts polarized immune responses from Th2 to Th1 in an antigen-specific manner. The molecular determinants governing the ability of DC to reprogram the polarity of T cell recall responses are not yet known. In addition to the expected role of T-bet expressed by T cells in regulating Th1 responses, we find using in vitro assays and an established in vivo model of allergic airway inflammation that T-bet expression by DC is also required for the polarity shift promoted by B7-DC XAb. T-bet expression by both T cells and DC is critically important for B7-DC XAb-induced down-regulation of IL-4, up-regulation of IFN-gamma and suppression of allergic airway inflammation. Moreover, retroviral reconstitution of T-bet expression in T-bet-deficient DC rescued their ability to modulate both naive and memory T-cell responses from Th2 to Th1. Our observations further our understanding of the critical mediators controlling the ability of DC to modify the responses of previously activated T cells and reveal the interesting use of the same transcription factor to regulate the inductive phenotype of DC and the inducible phenotype of T cells. | lld:pubmed |
| pubmed-article:18819071 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18819071 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18819071 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18819071 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18819071 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18819071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18819071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18819071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18819071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18819071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18819071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18819071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18819071 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18819071 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18819071 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:18819071 | pubmed:author | pubmed-author:IijimaKojiK | lld:pubmed |
| pubmed-article:18819071 | pubmed:author | pubmed-author:KitaHirohitoH | lld:pubmed |
| pubmed-article:18819071 | pubmed:author | pubmed-author:PeaseLarry... | lld:pubmed |
| pubmed-article:18819071 | pubmed:author | pubmed-author:SureshRadhakr... | lld:pubmed |
| pubmed-article:18819071 | pubmed:author | pubmed-author:PeikertTobias... | lld:pubmed |
| pubmed-article:18819071 | pubmed:author | pubmed-author:HeckmanKarin... | lld:pubmed |
| pubmed-article:18819071 | pubmed:author | pubmed-author:BellMichael... | lld:pubmed |
| pubmed-article:18819071 | pubmed:author | pubmed-author:McGregorHugh... | lld:pubmed |
| pubmed-article:18819071 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18819071 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:18819071 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18819071 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18819071 | pubmed:pagination | 2464-74 | lld:pubmed |
| pubmed-article:18819071 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:18819071 | pubmed:meshHeading | pubmed-meshheading:18819071... | lld:pubmed |
| pubmed-article:18819071 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18819071 | pubmed:articleTitle | T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation. | lld:pubmed |
| pubmed-article:18819071 | pubmed:affiliation | Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. | lld:pubmed |
| pubmed-article:18819071 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18819071 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:57765 | entrezgene:pubmed | pubmed-article:18819071 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18819071 | lld:entrezgene |
