|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0017262,
umls-concept:C0021368,
umls-concept:C0185117,
umls-concept:C0458827,
umls-concept:C0700624,
umls-concept:C1420610,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C2911684
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2008-10-1
|
|
pubmed:abstractText |
By cross-linking B7-DC on dendritic cells (DC) the human IgM antibody (B7-DC XAb) shifts polarized immune responses from Th2 to Th1 in an antigen-specific manner. The molecular determinants governing the ability of DC to reprogram the polarity of T cell recall responses are not yet known. In addition to the expected role of T-bet expressed by T cells in regulating Th1 responses, we find using in vitro assays and an established in vivo model of allergic airway inflammation that T-bet expression by DC is also required for the polarity shift promoted by B7-DC XAb. T-bet expression by both T cells and DC is critically important for B7-DC XAb-induced down-regulation of IL-4, up-regulation of IFN-gamma and suppression of allergic airway inflammation. Moreover, retroviral reconstitution of T-bet expression in T-bet-deficient DC rescued their ability to modulate both naive and memory T-cell responses from Th2 to Th1. Our observations further our understanding of the critical mediators controlling the ability of DC to modify the responses of previously activated T cells and reveal the interesting use of the same transcription factor to regulate the inductive phenotype of DC and the inducible phenotype of T cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1LG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1lg2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Ligand 2...,
http://linkedlifedata.com/resource/pubmed/chemical/T-Box Domain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/T-box transcription factor TBX21
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0014-2980
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
38
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2464-74
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:18819071-Adoptive Transfer,
pubmed-meshheading:18819071-Animals,
pubmed-meshheading:18819071-Antigens, CD80,
pubmed-meshheading:18819071-Cell Polarity,
pubmed-meshheading:18819071-Cells, Cultured,
pubmed-meshheading:18819071-Coculture Techniques,
pubmed-meshheading:18819071-Dendritic Cells,
pubmed-meshheading:18819071-Down-Regulation,
pubmed-meshheading:18819071-Inflammation,
pubmed-meshheading:18819071-Interferon-gamma,
pubmed-meshheading:18819071-Interleukin-4,
pubmed-meshheading:18819071-Lung,
pubmed-meshheading:18819071-Mice,
pubmed-meshheading:18819071-Mice, Inbred BALB C,
pubmed-meshheading:18819071-Mice, Inbred C57BL,
pubmed-meshheading:18819071-Mice, Knockout,
pubmed-meshheading:18819071-Ovalbumin,
pubmed-meshheading:18819071-Programmed Cell Death 1 Ligand 2 Protein,
pubmed-meshheading:18819071-Respiratory Hypersensitivity,
pubmed-meshheading:18819071-T-Box Domain Proteins,
pubmed-meshheading:18819071-Th1 Cells,
pubmed-meshheading:18819071-Th2 Cells,
pubmed-meshheading:18819071-Up-Regulation
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation.
|
|
pubmed:affiliation |
Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
