| pubmed-article:18818690 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C0812314 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C0020861 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:18818690 | lifeskim:mentions | umls-concept:C0240795 | lld:lifeskim |
| pubmed-article:18818690 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18818690 | pubmed:dateCreated | 2009-1-21 | lld:pubmed |
| pubmed-article:18818690 | pubmed:abstractText | Natural IgM are involved in numerous immunological functions but the genetic factors that control the homeostasis of its secretion and upholding remain unknown. Prompted by the finding that C57BL/6 mice had significantly lower serum levels of IgM when compared with BALB/c mice, we performed a genome-wide screen and found that the level of serum IgM was controlled by a QTL on chromosome 13 reaching the highest level of association at marker D13Mit266 (LOD score=3.54). This locus was named IgMSC1 and covered a region encompassing the interferon-regulatory factor 4 gene (Irf4). The number of splenic mature B cells in C57BL/6 did not differ from BALB/c mice but we found that low serum levels of IgM in C57BL/6 mice correlated with lower frequency of IgM-secreting cells in the spleen and in the peritoneal cavity. These results suggested that C57BL/6 mice have lower efficiency in late B-cell maturation, a process that is highly impaired in Irf4 knockout mice. In fact, we also found reduced Irf4 gene expression in B cells of C57BL/6 mice. Thus, we propose Irf4 as a candidate for the IgMSC1 locus, which controls IgM homeostatic levels at the level of B-cell terminal differentiation. | lld:pubmed |
| pubmed-article:18818690 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18818690 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18818690 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18818690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18818690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18818690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18818690 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18818690 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18818690 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18818690 | pubmed:issn | 1476-5470 | lld:pubmed |
| pubmed-article:18818690 | pubmed:author | pubmed-author:GarciaJJ | lld:pubmed |
| pubmed-article:18818690 | pubmed:author | pubmed-author:CoutinhoAA | lld:pubmed |
| pubmed-article:18818690 | pubmed:author | pubmed-author:DemengeotJJ | lld:pubmed |
| pubmed-article:18818690 | pubmed:author | pubmed-author:AlmeidaPP | lld:pubmed |
| pubmed-article:18818690 | pubmed:author | pubmed-author:RodoJJ | lld:pubmed |
| pubmed-article:18818690 | pubmed:author | pubmed-author:Penha-Gonçalv... | lld:pubmed |
| pubmed-article:18818690 | pubmed:author | pubmed-author:Côrte-RealJJ | lld:pubmed |
| pubmed-article:18818690 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18818690 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:18818690 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18818690 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18818690 | pubmed:pagination | 93-9 | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:meshHeading | pubmed-meshheading:18818690... | lld:pubmed |
| pubmed-article:18818690 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18818690 | pubmed:articleTitle | Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse. | lld:pubmed |
| pubmed-article:18818690 | pubmed:affiliation | Instituto Gulbenkian de Ciência, Oeiras, Portugal. | lld:pubmed |
| pubmed-article:18818690 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18818690 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16364 | entrezgene:pubmed | pubmed-article:18818690 | lld:entrezgene |
| entrez-gene:62816 | entrezgene:pubmed | pubmed-article:18818690 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18818690 | lld:entrezgene |
