Source:http://linkedlifedata.com/resource/pubmed/id/18818690
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2009-1-21
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pubmed:abstractText |
Natural IgM are involved in numerous immunological functions but the genetic factors that control the homeostasis of its secretion and upholding remain unknown. Prompted by the finding that C57BL/6 mice had significantly lower serum levels of IgM when compared with BALB/c mice, we performed a genome-wide screen and found that the level of serum IgM was controlled by a QTL on chromosome 13 reaching the highest level of association at marker D13Mit266 (LOD score=3.54). This locus was named IgMSC1 and covered a region encompassing the interferon-regulatory factor 4 gene (Irf4). The number of splenic mature B cells in C57BL/6 did not differ from BALB/c mice but we found that low serum levels of IgM in C57BL/6 mice correlated with lower frequency of IgM-secreting cells in the spleen and in the peritoneal cavity. These results suggested that C57BL/6 mice have lower efficiency in late B-cell maturation, a process that is highly impaired in Irf4 knockout mice. In fact, we also found reduced Irf4 gene expression in B cells of C57BL/6 mice. Thus, we propose Irf4 as a candidate for the IgMSC1 locus, which controls IgM homeostatic levels at the level of B-cell terminal differentiation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factors,
http://linkedlifedata.com/resource/pubmed/chemical/interferon regulatory factor-4
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1476-5470
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-9
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pubmed:meshHeading |
pubmed-meshheading:18818690-Animals,
pubmed-meshheading:18818690-B-Lymphocytes,
pubmed-meshheading:18818690-Chromosomes, Mammalian,
pubmed-meshheading:18818690-Genetic Markers,
pubmed-meshheading:18818690-Homeostasis,
pubmed-meshheading:18818690-Immunoglobulin M,
pubmed-meshheading:18818690-Interferon Regulatory Factors,
pubmed-meshheading:18818690-Lod Score,
pubmed-meshheading:18818690-Mice,
pubmed-meshheading:18818690-Mice, Inbred BALB C,
pubmed-meshheading:18818690-Mice, Inbred C57BL,
pubmed-meshheading:18818690-Peritoneal Cavity,
pubmed-meshheading:18818690-Quantitative Trait Loci,
pubmed-meshheading:18818690-Spleen
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pubmed:year |
2009
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pubmed:articleTitle |
Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse.
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pubmed:affiliation |
Instituto Gulbenkian de Ciência, Oeiras, Portugal.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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